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Titolo:
Siglecs, sialic acids and innate immunity
Autore:
Crocker, PR; Varki, A;
Indirizzi:
Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, ScotlandUniv Dundee Dundee Scotland DD1 5EH ust Bioctr, Dundee DD1 5EH, Scotland Univ Calif San Diego, Dept Med, Glycobiol Res & Training Ctr, La Jolla, CA92093 USA Univ Calif San Diego La Jolla CA USA 92093 ing Ctr, La Jolla, CA92093 USA Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 r Canc, La Jolla, CA 92093 USA
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 337 - 342
SICI:
1471-4906(200106)22:6<337:SSAAII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-REGULATORY PROTEIN; LEUKEMIC MYELOID CELLS; HUMAN BLOOD LEUKOCYTES; NATURAL-KILLER-CELLS; IMMUNOGLOBULIN SUPERFAMILY; INHIBITORY RECEPTOR; BINDING-RECEPTOR; MOLECULAR CHARACTERIZATION; SIALOADHESIN FAMILY; TISSUE MACROPHAGES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Crocker, PR Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH Dundee DD1 5EH, Scotland
Citazione:
P.R. Crocker e A. Varki, "Siglecs, sialic acids and innate immunity", TRENDS IMMU, 22(6), 2001, pp. 337-342

Abstract

Siglecs are members of the Ig superfamily that bind to sialic acid (Sia) and are mainly expressed by cells of the hematopoietic system. Until three years ago, only four Siglecs were known, namely sialoadhesin. CD22, myelin-associated glycoprotein and CD33. Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expressed by discrete subsets of leukocytes. Recognition of Sia by these Siglecs could play a role in the regulation of the innate immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:48:39