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Titolo:
Fishing for lymphoid genes
Autore:
Trede, NS; Zapata, A; Zon, LI;
Indirizzi:
Childrens Hosp, Div Hematol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Div Hematol, Boston, MA 02115 USA Howard Hughes Med Inst, Boston, MA 02115 USA Howard Hughes Med Inst Boston MA USA 02115 Med Inst, Boston, MA 02115 USA Univ Complutense, Fac Biol, Dept Cell Biol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 t Cell Biol, E-28040 Madrid, Spain
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 302 - 307
SICI:
1471-4906(200106)22:6<302:FFLG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOCYTE DEVELOPMENT; POSITIONAL CLONING; NEURAL CREST; ZEBRAFISH; THYMUS; MOUSE; MICE; DIFFERENTIATION; HEMATOPOIESIS; MUTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Trede, NS Childrens Hosp, Div Hematol, 320 Longwood Ave, Boston, MA 02115 USA Childrens Hosp 320 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
N.S. Trede et al., "Fishing for lymphoid genes", TRENDS IMMU, 22(6), 2001, pp. 302-307

Abstract

Thymic organogenesis and T-cell lymphopoiesis are crucial interdependent processes that establish a functional vertebrate immune system. The current understanding of vertebrate thymic development during embryogenesis remainsincomplete and would benefit from novel approaches. The zebrafish Danio rerio is a powerful developmental and genetic system for the dissection of early events in the ontogeny of the immune system. Forward genetic screens have uncovered genes involved in hematopoiesis, and specific screens are being designed to examine the genes that regulate T-cell development and the origin of the thymus. Studies of the zebrafish should improve our understanding of lymphoid development in vertebrates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:01:26