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Titolo:
Apoptosis as a determinant of atherothrombosis
Autore:
Tedgui, A; Mallat, Z;
Indirizzi:
Hop Lariboisiere, Inst Federatif Rech Circulat Paris 7, F-75475 Paris, France Hop Lariboisiere Paris France F-75475 lat Paris 7, F-75475 Paris, France
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 1, volume: 86, anno: 2001,
pagine: 420 - 426
SICI:
0340-6245(200107)86:1<420:AAADOA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ATHEROSCLEROTIC PLAQUES; SMOOTH-MUSCLE CELLS; ACUTE CORONARY SYNDROMES; SHED MEMBRANE MICROPARTICLES; TISSUE-FACTOR; MYOCARDIAL-INFARCTION; ARTERY DISEASE; PROCOAGULANT ACTIVITY; ENDOTHELIAL-CELLS; CIRCUMFERENTIAL STRESS;
Keywords:
atherosclerosis; plaque stability; apoptosis; tissue factor; phosphatidylserine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Tedgui, A INSERM U541, 41 Bd Chapelle, F-75475 Paris 10, France INSERM U541 41 Bd Chapelle Paris France 10 475 Paris 10, France
Citazione:
A. Tedgui e Z. Mallat, "Apoptosis as a determinant of atherothrombosis", THROMB HAEM, 86(1), 2001, pp. 420-426

Abstract

Clinical manifestations of atherosclerosis are the consequences of atherosclerotic plaque rupture that triggers thrombus formation. Tissue factor (TF) is a key element in the initiation of the coagulation cascade and is crucial in thrombus formation following plaque disruption. TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell. Apoptosis occurs in the human atherosclerotic plaque and shed membrane apoptotic microparticles rich in PS are produced in considerable amounts within the lipid core. These microparticles carry almost all TF activity and are responsible forthe procoagulant activity of the plaque. Moreover, luminal endothelial cell apoptosis might be responsible for thrombus formation on eroded plaques without rupture. Apoptosis might also play a major role in blood thrombogenicity via circulating procoagulant microparticles that are found at high levels in patients with acute coronary syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:25:53