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Titolo:
Integrin activation
Autore:
Woodside, DG; Liu, S; Ginsberg, MH;
Indirizzi:
Scripps Clin & Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 1, volume: 86, anno: 2001,
pagine: 316 - 323
SICI:
0340-6245(200107)86:1<316:IA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTION-ASSOCIATED ANTIGEN-1; GLYCOPROTEIN-IIB-IIIA; INTERCELLULAR-ADHESION MOLECULE-1; PLATELET GPIIB-IIIA; CATION-BINDING SITE; CELL-ADHESION; CYTOPLASMIC DOMAIN; LIGAND-BINDING; T-CELLS; I-DOMAIN;
Keywords:
integrin; adhesion; affinity regulation; cytoplasmic domain; transmembrane domain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Ginsberg, MH Scripps Clin & Res Inst, Dept Vasc Biol, VB-2,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst VB-2,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
D.G. Woodside et al., "Integrin activation", THROMB HAEM, 86(1), 2001, pp. 316-323

Abstract

Integrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize somerecent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis is placed on the regulation of integrin affinity for ligand (activation), although this is just one mechanism by which regulation of integrin-dependent cell adhesion can occur. Also discussed are recent observations on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand binding domain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:22:48