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Titolo:
The emerging role of the bone marrow-derived stem cells in (therapeutic) angiogenesis
Autore:
Carmellet, P; Luttun, A;
Indirizzi:
Katholieke Univ Leuven, Ctr Transgene Technol & Gene Therapy, Flanders Interuniv Inst Biotechnol, B-3000 Leuven, Belgium Katholieke Univ Leuven Leuven Belgium B-3000 nol, B-3000 Leuven, Belgium
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 1, volume: 86, anno: 2001,
pagine: 289 - 297
SICI:
0340-6245(200107)86:1<289:TEROTB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL PROGENITOR CELLS; IN-VITRO DIFFERENTIATION; RECEPTOR TYROSINE KINASE; VASCULAR SMOOTH-MUSCLE; GROWTH-FACTOR; TUMOR ANGIOGENESIS; POSTNATAL NEOVASCULARIZATION; CARDIOVASCULAR DEVELOPMENT; ANGIOBLAST MIGRATION; VASCULOGENIC MIMICRY;
Keywords:
angiogenesis; bone marrow cells; endothelial cells; multipotent progenitors; growth factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Carmellet, P Katholieke Univ Leuven, Ctr Transgene Technol & Gene Therapy,Flanders Interuniv Inst Biotechnol, Campus Gasthuisberg,Herestr 49, B-3000Leuven, Belgium Katholieke Univ Leuven Campus Gasthuisberg,Herestr 49 Leuven Belgium B-3000
Citazione:
P. Carmellet e A. Luttun, "The emerging role of the bone marrow-derived stem cells in (therapeutic) angiogenesis", THROMB HAEM, 86(1), 2001, pp. 289-297

Abstract

Proper formation of blood vessels (angiogenesis) is essential for development, reproduction and wound healing. When derailed, angiogenesis contributes to numerous lifethreatening disorders. While research has generally been focusing on the two main vascular cell types (endothelial and smooth musclecells), recent evidence indicates that bone marrow may also contribute to this process, both in the embryo and the adult. Novel vascular progenitors,even one common to both endothelial and smooth muscle cells, have been identified in the embryo. An exciting observation is that endothelial precursors have also been identified in the adult bone marrow. Transplantation studies revealed that these precursors as well as other bone marrow-derived cells contribute to the growth of endothelium-lined vessels (angiogenesis) as well as the expansion of pre-existing collaterals (arteriogenesis) in ischemic disease. These findings have raised hopes that bone marrow-derived cells might one day become useful for cell-based angiogenic therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:08:24