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Titolo:
Cytoskeletal proteins and platelet signaling
Autore:
Fox, JEB;
Indirizzi:
Cleveland Clin Fdn, Dept Mol Cardiol, Joseph J Jacobs Ctr Thrombosis Vasc Biol, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 s Inst, Cleveland, OH 44195 USA Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH USA Case Western Reserve Univ Cleveland OH USA & Biophys, Cleveland, OH USA
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 1, volume: 86, anno: 2001,
pagine: 198 - 213
SICI:
0340-6245(200107)86:1<198:CPAPS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIN-BINDING PROTEIN; VASODILATOR-STIMULATED PHOSPHOPROTEIN; GLYCOPROTEIN-IIB-IIIA; INTACT HUMAN-PLATELETS; THROMBIN-ACTIVATED PLATELETS; INTEGRIN BETA(3) SUBUNIT; HUMAN BLOOD-PLATELETS; RICH FOCAL ADHESION; RHO-FAMILY GTPASES; IB-IX COMPLEX;
Keywords:
cytoskeleton; signaling; platelet shape; spatial organizations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
208
Recensione:
Indirizzi per estratti:
Indirizzo: Fox, JEB Cleveland Clin Fdn, Dept Mol Cardiol, Joseph J Jacobs Ctr Thrombosis Vasc Biol, Lerner Res Inst, 9500 Euclid Ave,NB-50, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave,NB-50 Cleveland OH USA 44195 A
Citazione:
J.E.B. Fox, "Cytoskeletal proteins and platelet signaling", THROMB HAEM, 86(1), 2001, pp. 198-213

Abstract

The actin filament network fills the cytoplasm of unstimulated platelets and connects with a submembranous latticework of short cross-linked actin filaments, known as the membrane skeleton. One function of the cytoskeleton is to direct the contours of the membrane in the unstimulated platelet and the rapid changes in shape in the activated platelet. Activation-induced changes result from events such as phosphorylation or calpain-induced cleavageof cytoskeletal proteins. The specific reorganizations depend upon the combination of signals to which platelets are exposed. A second function of the cytoskeleton is to bind other cellular components; it binds signaling molecules, localizing them to specific cellular locations; it binds the plasmamembrane regulating properties of the membrane, maintaining microdomains in the membrane, or regulating activities of membrane proteins. In this way,the cytoskeleton plays a critical role in regulation of spatial organizations and, thus, in the integration of cellular activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:35:39