Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis
Autore:
De Iaco, PA; Muzzupapa, G; Bigon, E; Pressato, D; Dona, M; Pavesio, A; Bovicelli, L;
Indirizzi:
Univ Bologna, Osped S Orsola, Clin Ostetr & Ginecol, Dept Obstet & Gynecol, I-40138 Bologna, Italy Univ Bologna Bologna Italy I-40138 tet & Gynecol, I-40138 Bologna, Italy Fidia Adv Biopolymers Srl, Abano Terme, Italy Fidia Adv Biopolymers Srl Abano Terme Italy ers Srl, Abano Terme, Italy
Titolo Testata:
SURGERY
fascicolo: 1, volume: 130, anno: 2001,
pagine: 60 - 64
SICI:
0039-6060(200107)130:1<60:EOAHDG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODEL; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: De Iaco, PA Univ Bologna, Osped S Orsola, Clin Ostetr & Ginecol, Dept Obstet & Gynecol, Massarenti 13, I-40138 Bologna, Italy Univ Bologna Massarenti13 Bologna Italy I-40138 logna, Italy
Citazione:
P.A. De Iaco et al., "Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis", SURGERY, 130(1), 2001, pp. 60-64

Abstract

Background. We previously demonstrated that an auto-cross-linked hyaluronan-based antiadhesion agent (auto-moss-linked polysaccharide [ACP] gel) was effective in postsurgical adhesion prevention after open laparotomy and laparoscopic surgery with adequate hemostasis in animal,models. This study assessed the ability of different preparations of ACP gel to prevent adhesionsin the presence of bleeding or inadequate hemostasis. Methods. Ninety-seven female rabbits were subjected to a standardized surgical lesion with subsequent exudative abdominal bleeding tooting model, and97 animals were subjected to a standardized surgical lesion with severe abdominal bleeding (bleeding model). After injury, the animals were randomly assigned to 5 groups of treatment: 3 different preparations of ACP gel (20,40, anti 60 mg/mL), a hyaluronan-carboxymethylcellulose film, and no treatment. Three weeks after operation the animals were Killed, and the adhesions were assessed by a blinded observer who measured thr length and area of the adhesions and who used the Blauer scoring system. Results. All 3 preparations of A cp gel and the hyaluronan -carboxymethylcellulose film reduced adhesion formation in both models (P < .01) as measured by the number of adhesion-free animals, mean Blauer score, and the mean length and surface area of the adhesions. There were no statistical differences between the different treatment groups. Conclusions.. These data suggest that different hyaluronan based agents inthe presence of severe bleeding or exudative abdominal bleeding reduce de-novo postsurgical adhesion formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:55:33