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Titolo:
The induction of angiogenesis by the implantation of autologous bone marrow cells: A novel and simple therapeutic method
Autore:
Hamano, K; Li, TS; Kobayashi, T; Tanaka, N; Kobayashi, S; Matsuzaki, M; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Radiol, Ube, Yamaguchi, Japan Yamaguchi Univ Ube Yamaguchi Japan d, Dept Radiol, Ube, Yamaguchi, Japan Yamaguchi Univ, Sch Med, Dept Physiol 1, Ube, Yamaguchi, Japan Yamaguchi Univ Ube Yamaguchi Japan Dept Physiol 1, Ube, Yamaguchi, Japan Yamaguchi Univ, Sch Med, Dept Internal Med 2, Ube, Yamaguchi, Japan Yamaguchi Univ Ube Yamaguchi Japan Internal Med 2, Ube, Yamaguchi, Japan
Titolo Testata:
SURGERY
fascicolo: 1, volume: 130, anno: 2001,
pagine: 44 - 54
SICI:
0039-6060(200107)130:1<44:TIOABT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; COLLATERAL VESSEL DEVELOPMENT; GENE-TRANSFER; MODEL; RAT; ISCHEMIA; HEART; TRANSPLANTATION; PHVEGF(165); EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hamano, K Yamaguchi Univ, Sch Med, Dept Surg 1, 1-1-1 Minami Kogushi, Ube,Yamaguchi7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505
Citazione:
K. Hamano et al., "The induction of angiogenesis by the implantation of autologous bone marrow cells: A novel and simple therapeutic method", SURGERY, 130(1), 2001, pp. 44-54

Abstract

Background. Bone marrow contains many kinds of primitive cells that could differentiate to endothelial cells and secrete several growth factors. In the current study, we attempted to induce therapeutic angiogenesis by implanting autologous bone marrow cells (BMCs) and using a rat ischemic hind limbmodel. Methods. BMCs were prepared by removing red blood cells. A rat ischemic hind limb model was made by the ligation of the left femoral artery and its branches. BMCs were injected into 7 points of the ischemic muscles. To assess angiogenesis, a microangiogram, laser Doppler, and histologic evaluation were performed after the surgical procedure. Results. A microangiogram and histologic evaluation showed that angiogenesis was significantly induced in the ischemic hind limb by the implantation of BMCs. Laser Doppler imaging analysis showed that blood flow was significantly increased after implantation of BMCs. Some implanted BMCs were stained positively with CD31 and vascular endothelial-cadherin (VE-cadherin), which might have been incorporated into the vasculature. The condition of ischemia caused an elevation in the level of basic fibroblast growth factor in the ischemic muscle and also in interleukin-1 beta derived from the implanted BMCs, which might contribute to angiogenesis. Conclusion. These findings indicate that autologous bone marrow implantation may be a novel and simple method for inducing therapeutic angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:25:50