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Titolo:
The role of semen in induction of maternal immune tolerance to pregnancy
Autore:
Robertson, SA; Sharkey, DJ;
Indirizzi:
Univ Adelaide, Dept Obstet & Gynaecol, Adelaide, SA 5005, Australia Univ Adelaide Adelaide SA Australia 5005 ol, Adelaide, SA 5005, Australia Univ Adelaide, Reprod Med Unit, Adelaide, SA 5005, Australia Univ Adelaide Adelaide SA Australia 5005 it, Adelaide, SA 5005, Australia
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 243 - 254
SICI:
1044-5323(200108)13:4<243:TROSII>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SEMINAL PLASMA; T-CELL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; COLONY-STIMULATING FACTOR; PATERNAL ALLOANTIGENS; EPITHELIAL-CELLS; ANTIGEN EXPRESSION; MURINE PREGNANCY; CUTTING EDGE; MOUSE UTERUS;
Keywords:
embryo; pregnancy; seminal plasma; sperm; tolerance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, SA Univ Adelaide, Dept Obstet & Gynaecol, Adelaide, SA 5005, Australia Univ Adelaide Adelaide SA Australia 5005 SA 5005, Australia
Citazione:
S.A. Robertson e D.J. Sharkey, "The role of semen in induction of maternal immune tolerance to pregnancy", SEMIN IMMUN, 13(4), 2001, pp. 243-254

Abstract

Successful pregnancy requires a state of maternal immune 'tolerance' to accommodate antigens expressed by the conceptus. Implantation failure and placental pathologies largely reflect insufficiencies in maternal immune adaptation, but progress in devising therapeutic strategies to treat these conditions is stalled because the mechanisms underlying the induction and maintenance of maternal tolerance are unknown. Increasingly, clinical and experimental data support the proposal that insemination has consequences for the reproductive process beyond delivery of male gametes. An emerging hypothesis, based mainly on clinical observations and experiments in mice, is that insemination is causally linked to the activation and expansion of populations of lymphocytes mediating forms of 'active' immune tolerance in the implantation site. This review examines existing evidence for a role for semen in the immunology of pregnancy, highlighting the limitations of our existingknowledge and the prospects for future research and its clinical application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:35:27