Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance
Autore:
Hrycyna, CA;
Indirizzi:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ W LafayetteIN USA 47907 Dept Chem, W Lafayette, IN 47907 USA
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 247 - 256
SICI:
1084-9521(200106)12:3<247:MGAABC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED ATPASE ACTIVITY; NUCLEOTIDE-BINDING SITES; CATALYTIC TRANSITION-STATE; MULTIPLE-DRUG RESISTANCE; 6TH TRANSMEMBRANE DOMAIN; SUBSTRATE-SPECIFICITY; MUTATIONAL ANALYSIS; VACCINIA VIRUS; FUNCTIONAL CONSEQUENCES; DEPENDENT TRANSPORT;
Keywords:
ABC superfamily; chemotherapy; P-glycoprotein; multidrug resistance; mutational analysis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Hrycyna, CA Purdue Univ, Dept Chem, 1393 Brown Bldg, W Lafayette, IN 47907USA Purdue Univ 1393 Brown Bldg W Lafayette IN USA 47907 47907 USA
Citazione:
C.A. Hrycyna, "Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance", SEM CELL D, 12(3), 2001, pp. 247-256

Abstract

A variety of human cancers become resistant or are intrinsically resistantto treatment with conventional drug therapies. This phenomenon is due in large part to the overexpression of a 170 kDa plasma membrane ATP-dependent pump known as the multidrug resistance transporter or P-glycoprotein. P-glycoprotein is a member of the large ATP binding cassette (ABC) superfamily of membrane transporters. This review focuses on the use of structure-function analyses to elucidate further the mechanism of action mammalian P-glycoproteins. Ultimately, a complete understanding of the mechanism is importantfor the development of novel strategies for the treatment of many human cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:35:06