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Titolo:
Increased expression of atrial natriuretic peptide in ureteral obstructed kidneys in rats.
Autore:
Kim, SW; Lee, JU; Choi, KC;
Indirizzi:
Chonnam Natl Univ, Sch Med, Dept Internal Med, Kwangju 501757, South KoreaChonnam Natl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea Chonnam Natl Univ, Sch Med, Dept Physiol, Kwangju 501757, South Korea Chonnam Natl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea Chonnam Natl Univ, Res Inst Med Sci, Kwangju 501757, South Korea Chonnam Natl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea
Titolo Testata:
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
fascicolo: 3, volume: 35, anno: 2001,
pagine: 163 - 168
SICI:
0036-5599(200106)35:3<163:IEOANP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANYLATE-CYCLASE; SODIUM-EXCRETION; RECEPTOR; LOCALIZATION; ATRIOPEPTIN;
Keywords:
ureteral obstruction; atrial natriuretic peptide; natriuretic peptide receptor-A; guanylyl cyclase activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, KC Chonnam Natl Univ, Sch Med, Dept Internal Med, 8 Hak Dong, Kwangju 501757,South Korea Chonnam Natl Univ 8 Hak Dong Kwangju South Korea 501757 th Korea
Citazione:
S.W. Kim et al., "Increased expression of atrial natriuretic peptide in ureteral obstructed kidneys in rats.", SC J UROL N, 35(3), 2001, pp. 163-168

Abstract

Objectives: Whether the natriuresis in the previously ureteral obstructed kidney may be related to an altered regulation of local atrial natriuretic peptide (ANP) was investigated. Materials and Methods: Male Sprague-Dawley rats were unilaterally obstructed of the left ureters for 48 hours. The left and right ureters were separately cannulated to collect urine samples. In some rats, both kidneys were removed without releasing the obstruction. Control rats were treated the same except that no ureteral obstruction was made. The mRNA expression of ANP and natriuretic peptide receptor (NPR)-A was determined in the kidney by reverse transcription-polymerase chain reaction. The guanylyl cyclase activity was, measured by the amount of cGMP generated in response to ANP. Plasma levels of ANP were measured by radioimmunoassay. Results: The ureteral obstruction did not significantly affect the plasma ANP levels. In the obstructed kidney, the creatinine clearance was decreased, while the fractional excretion of sodium increased. The expression of ANP mRNA was increased in the obstructed kidney. The NPR-A mRNA expression was not altered in the glomerulus. but was decreased in the papilla of the obstructed kidney. Nor was the guanylyl cyclase activity in the glomerulus altered. Although the guanylyl cyclase activity in the papilla was significantly decreased in the obstructed kidney, it was rapidly resumed upon releasing the obstruction. Conclusions: An increased local expression of ANP may. at least in part, account for the natriuresis in the previously ureteral obstructed kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 03:01:26