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Titolo:
Human antimicrobial peptides
Autore:
Ryley, HC;
Indirizzi:
Univ Wales Coll Med, Dept Med Microbiol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales
Titolo Testata:
REVIEWS IN MEDICAL MICROBIOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 177 - 186
SICI:
0954-139X(200107)12:3<177:HAP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN NEUTROPHIL DEFENSINS; INNATE HOST-DEFENSE; CANDIDA-ALBICANS; CYSTIC-FIBROSIS; HUMAN BETA-DEFENSIN-2; AIRWAY SURFACE; ALPHA-DEFENSINS; BETA-DEFENSINS; CELL-DEATH; HUMAN LUNG;
Keywords:
alpha-defensin; beta-defensin; cathelicidin; histatin; thrombocidin; antibacterial agent; innate immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Ryley, HC Univ Wales Hosp, Univ Wales Coll Med, Dept Med Microbiol, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales Hosp Heath Pk Cardiff S GlamWales CF14 4XN am, Wales
Citazione:
H.C. Ryley, "Human antimicrobial peptides", REV MED MIC, 12(3), 2001, pp. 177-186

Abstract

Antimicrobial peptides are ancient in origin but are thought to play an important integral role in human innate immunity. In recent years, there has been an increased understanding of the diversity of animal antimicrobial peptides in general and human antimicrobial peptides in particular. Currently, five families of antimicrobial peptides have been described in humans. These are the alpha-defensins with six members, the beta-defensins with two members, a single cathelicidin, LL-37, the histatin family with three main members and the recently described two thrombin-induced platelet antimicrobial peptides (the thrombocidins). With the exception of LL-37, families of antimicrobial peptides are associated with specific tissues. A number of antimicrobial peptides may be generated in vitro by non-specific proteolysis of extracellular proteins. Two of these, the acidic antimicrobial peptides and lactoferricin derived by pepsin digestion of lactoferrin may have roles in vivo. Recent work has demonstrated that the expressions of several peptides are upregulated by inflammation, beta-defensin 2 and LL-37. There is also a growing appreciation of the synergistic activity that may be found both between some peptide families and other antimicrobial proteins of the innate immune system. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:19:02