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Titolo:
Rapid and sensitive quantitation of antibiotics in fermentations by electrospray mass spectrometry
Autore:
Morgan, J; Joyce-Menekse, ME; Rowlands, RT; Gilbert, IH; Lloyd, D;
Indirizzi:
Dragon Associates, Cardiff CF15 9NU, S Glam, Wales Dragon Associates Cardiff S Glam Wales CF15 9NU f CF15 9NU, S Glam, Wales Univ Wales Coll Cardiff, Sch Biosci, Microbiol Grp, Cardiff CF1 3TL, S Glam, Wales Univ Wales Coll Cardiff Cardiff S Glam Wales CF1 3TL 1 3TL, S Glam, Wales Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales Univ Wales Coll Cardiff Cardiff S Glam Wales CF1 3XF 1 3XF, S Glam, Wales
Titolo Testata:
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
fascicolo: 14, volume: 15, anno: 2001,
pagine: 1229 - 1238
SICI:
0951-4198(2001)15:14<1229:RASQOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; BETA-LACTAM ANTIBIOTICS; AMINOGLYCOSIDE ANTIBIOTICS; PRECOLUMN DERIVATIZATION; ULTRAVIOLET DETECTION; CONFIRMATORY ASSAY; PENICILLIN-G; HUMAN PLASMA; BOVINE-MILK; IONIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Rowlands, RT Dragon Associates, 10 Parc Castell Mynach, Cardiff CF15 9NU, S Glam, Wales Dragon Associates 10 Parc Castell Mynach Cardiff S Glam WalesCF15 9NU
Citazione:
J. Morgan et al., "Rapid and sensitive quantitation of antibiotics in fermentations by electrospray mass spectrometry", RAP C MASS, 15(14), 2001, pp. 1229-1238

Abstract

Electrospray ionisation mass spectrometry (ESI-MS) has been used for the determination and quantitation of a broad range of 24 antibiotics, from groups including aminoglycosides, beta -lactams, tetracyclines, antifungals andglycopeptides. Spectra have been acquired for all 24 antibiotics derived from pure samples dissolved in acetonitrile/water, along with samples extracted from complex fermentation liquor. Quantitation was carried out by the detection of the protonated molecules, using time-scheduled single-ion monitoring (SIM). ESI-MS was used to detect and quantify to 5-muM levels. A one-step extraction of antibiotics with an organic solvent (methanol) was used for this rapid and simple procedure. Specificity is not matched by other methods and antibiotic analogues (e.g. the five forms of erythromycin) can bedetermined within minutes. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:47:46