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Titolo:
Recently diagnosed sexually HIV-infected patients: seroconversion interval, partner notification period and a high yield of HIV diagnoses among partners
Autore:
Worm, AM; Bird, SM; Holmstrom, P; Smith, E; Valle, SL; Colpin, H; Clumeck, N; Worm, AM; Smith, E; Fenton, K; French, R; Holmstrom, P; Haikala, O; Valle, SL; Roumeliotou, A; Papaevangelou, G; Moi, H; Due-Tonnesen, U; Bird, SM; Mir, N; Ramstedt, K; Raado, G;
Indirizzi:
MRC, Biostat Unit, Cambridge CB2 2SR, England MRC Cambridge England CB2 2SR , Biostat Unit, Cambridge CB2 2SR, England Hop St Pierre, Div Infect Dis, Brussels, Belgium Hop St Pierre Brussels Belgium ierre, Div Infect Dis, Brussels, Belgium State Serum Inst, Dept Epidemiol, Copenhagen, Denmark State Serum Inst Copenhagen Denmark Dept Epidemiol, Copenhagen, Denmark Bispebjerg Hosp, Dept Dermatovenerol, DK-2400 Copenhagen, Denmark Bispebjerg Hosp Copenhagen Denmark DK-2400 , DK-2400 Copenhagen, Denmark Mortimer Market Ctr, London, England Mortimer Market Ctr London EnglandMortimer Market Ctr, London, England Univ Helsinki, Cent Hosp, Helsinki, Finland Univ Helsinki Helsinki Finland v Helsinki, Cent Hosp, Helsinki, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland Athens Sch Publ Hlth, Athens, Greece Athens Sch Publ Hlth Athens GreeceAthens Sch Publ Hlth, Athens, Greece Olafiaklinikken, Oslo, Norway Olafiaklinikken Oslo NorwayOlafiaklinikken, Oslo, Norway Glasgow Royal Infirm, Dept Genitourinary Med, Glasgow G4 0SF, Lanark, Scotland Glasgow Royal Infirm Glasgow Lanark Scotland G4 0SF 0SF, Lanark, Scotland Natl Publ Hlth Inst, Stockholm, Sweden Natl Publ Hlth Inst Stockholm Sweden Publ Hlth Inst, Stockholm, Sweden
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 7, volume: 94, anno: 2001,
pagine: 379 - 390
SICI:
1460-2725(200107)94:7<379:RDSHPS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PREVENTION; EXPERIENCE; PROPHYLAXIS; DISCLOSURE; ATTITUDES; COMMUNITY; EXPOSURE; CAROLINA; CLINICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bird, SM MRC, Biostat Unit, Robinson Way, Cambridge CB2 2SR, England MRC Robinson Way Cambridge England CB2 2SR idge CB2 2SR, England
Citazione:
A.M. Worm et al., "Recently diagnosed sexually HIV-infected patients: seroconversion interval, partner notification period and a high yield of HIV diagnoses among partners", QJM-MON J A, 94(7), 2001, pp. 379-390

Abstract

We collected data on the outcome of partner notification (PN) for 356 index patients (iPs) newly diagnosed with HIV, all sexually infected, in six European countries, 1995-96. The PN period (the period during which exposed partners should be notified about their risk of being HIV infected) could bedefined on the basis of last negative HIV test in 170/356 (48%), from other key dates for 12, and for 14 more on the sole basis of known HIV exposure(total 196/356, 55%), However, of the 170 iPs with a last negative HIV test date, PN period was not defined in 52 (31%), even though 28/52 were recent seroconverters (negative HIV test within 24 months of HIV diagnosis). Discrepancies in PN period evaluation were common: of the 85 iPs for whom PN period was reportedly defined as '3 months before last HIV-negative date', the period actually used was equal to this in only 12. A user-friendly worksheet would simplify the task of eliciting and using key dates to define thePN period. Forms on PN outcome were received for 166/200 (83%) reported current partners, but only 124/508 (24%) ex-partners. Fifty-two of 290 (18%) notified partners already knew they were HIV-positive, and 38/130 (29%) notified partners for whom pre-PN status was negative or unknown were HIV-positive on post-PN testing. Results of HIV tests (if any) after PN were unknown for 37/133 (28%) current partners not already known to be HIV-positive, and for 71/105 (68%) ex-partners-a doubling of the information loss rate. Notification of 133 current and 105 ex-partners not previously identified as HIV-positive thus produced 28 (21%) and 10 (10%) new HIV diagnoses, respectively. The total yield of HIV diagnoses was 38/100 (38%) partners of recentseroconverters (22 already known plus 16 PN-diagnosed), compared with 52/190 (27%) partners of other iPs (30 already known plus 22 PN-diagnosed). We propose prioritization for PN of partners of recent seroconverters, augmented surveillance for HIV diagnoses and recurrence in PN networks of at-risk,non-notified partners, and new measures that preserve anonymity to alert potential and past sexual contacts of HIV-diagnosed individuals who are unable or unwilling to assist in PN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:14:19