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Titolo:
Binding of [H-3]paroxetine to serotonin uptake sites and of [H-3]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment
Autore:
Bixo, M; Allard, P; Backstrom, T; Mjorndal, T; Nyberg, S; Spigset, O; Sundstrom-Poromaa, I;
Indirizzi:
Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90185 Umea, Sweden Umea UnivUmea Sweden S-90185 Sci Obstet & Gynecol, S-90185 Umea, Sweden Umea Univ, Dept Psychiat, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 Univ, Dept Psychiat, S-90185 Umea, Sweden Umea Univ, Dept Clin Neurosci & Pharmacol, S-90185 Umea, Sweden Umea UnivUmea Sweden S-90185 Neurosci & Pharmacol, S-90185 Umea, Sweden Reg & Univ Hosp, Dept Clin Pharmacol, Trondheim, Norway Reg & Univ Hosp Trondheim Norway Dept Clin Pharmacol, Trondheim, Norway
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 6, volume: 26, anno: 2001,
pagine: 551 - 564
SICI:
0306-4530(200108)26:6<551:BO[TSU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; IMIPRAMINE BINDING; DEPRESSED-PATIENTS; MENSTRUAL-CYCLE; SERTRALINE TREATMENT; HEALTHY-VOLUNTEERS; TENSION SYNDROME; GNRH-AGONIST; TRANSPORTER; BRAIN;
Keywords:
premenstrual dysphoric disorder; GnRH-agonist; serotonin; paroxetine; lysergic acid diethylamide; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bixo, M Umea Univ, Dept Clin Sci Obstet & Gynecol, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 et & Gynecol, S-90185 Umea, Sweden
Citazione:
M. Bixo et al., "Binding of [H-3]paroxetine to serotonin uptake sites and of [H-3]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment", PSYCHONEURO, 26(6), 2001, pp. 551-564

Abstract

Changes in serotonergic parameters have been reported in psychiatric conditions such as depression but also in the premenstrual dysphoric disorder (PMDD). In addition, hormonal effects on serotonergic activity have been established. In the present;study, binding of [H-3]paroxetine to platelet serotonin uptake sites: and binding of [H-3]lysergic acid diethylamide ([H-3]LSD) to platelet serotonin (5-HT)(2A) receptors were studied in patients with PMDD treated with a low dose of a gonadotropin releasing hormone (GnRH) agonist (buserelin) or placebo and compared to controls. The PMDD patients were relieved of premenstrual symptoms like depression and irritability duringbuserelin treatment. The number of [H-3]paroxetine binding sites (B-max) were significantly higher in the follicular phase in untreated PMDD patientscompared to controls. When treated with buserelin the difference disappeared. No differences in [ H-3]LSD binding between the three groups were shown. The present study demonstrated altered platelet [3H]paroxetine binding characteristics in women with PMDD compared to controls. Furthermore, [H-3]paroxetine binding was affected by PMDD treatment with a low dose of buserelin. The results are consistent with the hypothesis that changes in serotonergic transmission could be a trait in the premenstrual dysphoric disorder. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:46:39