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Titolo:
Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder
Autore:
Radant, A; Tsuang, D; Peskind, ER; McFall, M; Raskind, W;
Indirizzi:
VA Med Ctr, Puget Sound Hlth Care Syst, Mental Hlth Serv,VA Puget Sound, Vet Affairs NE Network MIRECC, Seattle, WA 98108 USA VA Med Ctr Seattle WA USA 98108 NE Network MIRECC, Seattle, WA 98108 USA Univ Washington, Dept Psychiat & Biobehav Sci, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Biobehav Sci, Seattle, WA 98195 USA Univ Washington, Dept Internal Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Internal Med, Seattle, WA 98195 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 3, volume: 102, anno: 2001,
pagine: 203 - 215
SICI:
0165-1781(20010724)102:3<203:BMADAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ALZHEIMERS-DISEASE; URINARY CORTISOL EXCRETION; CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID RECEPTOR NUMBER; JUVENILE MYOCLONIC EPILEPSY; NATIONAL COMORBIDITY SURVEY; CHILDHOOD SEXUAL ABUSE; HIPPOCAMPAL VOLUME; VIETNAM VETERANS; RISK-FACTORS;
Keywords:
startle reaction; hippocampus; comorbidity; heritability; hypothalamic hormones;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Radant, A VA Med Ctr, Puget Sound Hlth Care Syst, Mental Hlth Serv,VA Puget Sound, Vet Affairs NE Network MIRECC, 116-MHC,1660 S Columbian Way, Seattle, WA 98108 USA VA Med Ctr 116-MHC,1660 S Columbian Way Seattle WA USA 98108 USA
Citazione:
A. Radant et al., "Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder", PSYCHIAT R, 102(3), 2001, pp. 203-215

Abstract

Family End twin studies suggest a substantial genetic contribution to the etiology of posttraumatic stress disorder (PTSD). Identification of the nature of this genetic contribution should enhance understanding of the pathophysiology of PTSD and suggest improved therapeutic strategies for its treatment. However, a broadly defined phenotype, specific requirement for an environmental exposure and high frequency of comorbid psychiatric illness all complicate genetic studies of PTSD, It is likely that genetic heterogeneity, incomplete penetrance, pleiotropy and the involvement of more than one gene all constitute formidable obstacles to the genetic analysis of PTSD. Oneway to circumvent these problems is to perform genetic analysis of traits associated with PTSD, rather than PTSD itself, an approach that has been fruitful for other diseases with complex modes of inheritance. Hypothalamic-pituitary-adrenal axis hypofunction, physiologic markers of increased arousal, and increased acoustic startle response are all potential PTSD-associated traits that might be susceptible to genetic analysis. However, the capacity of these traits to distinguish PTSD from non-PTSD patients and their familial pattern must be better defined before they can be employed in geneticstudies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:48:03