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Titolo:
Superoxide generation of phagocytes and nonphagocytic cells
Autore:
Meier, B;
Indirizzi:
BCM Res, D-85307 Entrischenbrunn 12, Germany BCM Res Entrischenbrunn Germany 12 , D-85307 Entrischenbrunn 12, Germany Tierarztlichen Hsch Hannover, D-3000 Hannover, Germany Tierarztlichen HschHannover Hannover Germany D-3000 0 Hannover, Germany
Titolo Testata:
PROTOPLASMA
fascicolo: 1-3, volume: 217, anno: 2001,
pagine: 117 - 124
SICI:
0033-183X(2001)217:1-3<117:SGOPAN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC GRANULOMATOUS-DISEASE; RESPIRATORY BURST OXIDASE; VASCULAR SMOOTH-MUSCLE; NEUTROPHIL NADPH OXIDASE; HUMAN-ENDOTHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; RAT MESANGIAL CELLS; REACTIVE OXYGEN METABOLITES; DEPENDENT H2O2 GENERATION; PLASMA-MEMBRANE;
Keywords:
superoxide; fibroblast; phagocyte; NADH-oxidase; NADPH-oxidase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Meier, B BCM Res, D-85307 Entrischenbrunn 12, Germany BCM Res Entrischenbrunn Germany 12 Entrischenbrunn 12, Germany
Citazione:
B. Meier, "Superoxide generation of phagocytes and nonphagocytic cells", PROTOPLASMA, 217(1-3), 2001, pp. 117-124

Abstract

Phagocytes release high amounts of reactive oxygen intermediates upon contact with appropriate stimuli into the environment as an important function in the immune defence against infectious agents. On the other hand nonphagocytic cells release low amounts upon stimulation, which have important functions in the inter- and intracellular signal transduction. Both systems represent a class of isoenzymes making a specific regulation possible. Fibroblasts, hepatocytes, and HeLa cells possess a superoxide system which shows higher activity with NADH than NADPH. The enzyme was purified to homogeneityin an active form, showed a molecular mass of 84 kDa and possessed a flavin and low-potential cytochrome b(558).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:29:37