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Titolo:
Creutzfeldt-Jakob disease: A protein disease
Autore:
Knight, R;
Indirizzi:
Western Gen Hosp, Natl CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland
Titolo Testata:
PROTEOMICS
fascicolo: 6, volume: 1, anno: 2001,
pagine: 763 - 766
SICI:
1615-9853(200106)1:6<763:CDAPD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRAIN VARIATION; VARIANT CJD; DIAGNOSIS; BRAIN; PRPSC; GENE;
Keywords:
Creutzfeldt-Jakob disease; prion protein; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Knight, R Western Gen Hosp, Natl CJD Surveillance Unit, Crewe Rd, Edinburgh EH4 2XU,Midlothian, Scotland Western Gen Hosp Crewe Rd Edinburgh Midlothian Scotland EH4 2XU
Citazione:
R. Knight, "Creutzfeldt-Jakob disease: A protein disease", PROTEOMICS, 1(6), 2001, pp. 763-766

Abstract

Creutzfeld-Jakob disease (CJD) is essentially a protein disease. All formsof CJD are characterized by the deposition of an abnormal coformation of anormal cellular protein. This protein (PrPC) is encoded for by the PRNP gene on chromosome 20 in humans. There are important genetic influences on susceptibility to CJD and on the resulting clinico-pathological picture. The abnormal protein (PrPSc), may be the infectious agent itself or the main component of it. However, its precise role in the pathogenesis of disease is not clear. The detection of PrPSC plays a crucial role in the diagnosis of CJD and its electrophoretic characteristics are used to classify different forms of CJD. However, the "molecular diagnosis" of CJD is not without uncertainties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:40:10