Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress
Autore:
Brunson, KL; Eghbal-Ahmadi, M; Bender, R; Chen, YC; Baram, TZ;
Indirizzi:
Univ Calif Irvine, Dept Anat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 nat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pediat, Irvine, CA 92697 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 15, volume: 98, anno: 2001,
pagine: 8856 - 8861
SICI:
0027-8424(20010717)98:15<8856:LPHCLA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; AGE-RELATED IMPAIRMENTS; RAT-BRAIN; IMMATURE RAT; NONHUMAN-PRIMATES; NEURON NUMBER; ADULT-RATS; FACTOR CRF; RECEPTOR; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Baram, TZ Univ Calif Irvine, Dept Anat Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol, Irvine, CA 92697 USA
Citazione:
K.L. Brunson et al., "Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress", P NAS US, 98(15), 2001, pp. 8856-8861

Abstract

Stress early in postnatal life may result in long-term memory deficits andselective loss of hippocampal neurons. The mechanisms involved are poorly understood, but they may involve molecules and processes in the immature limbic system that are activated by stressful challenges. We report that administration of corticotropin-releasing hormone (CRH), the key limbic stress modulator, to the brains of immature rats reproduced the consequences of early-life stress, reducing memory functions throughout life. These deficits were associated with progressive loss of hippocampal CA3 neurons and chronic up-regulation of hippocampal CRH expression. Importantly, they did not require the presence of stress levels of glucocorticoids. These findings indicate a critical role for CRH in the mechanisms underlying the long-term effects of early-life stress on hippocampal integrity and function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:32:42