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Titolo:
Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester
Autore:
Spencer, K; Liao, AW; Ong, CYT; Geerts, L; Nicolaides, KH;
Indirizzi:
Harold Wood Hosp, Dept Clin Biochem, Endocrine Unit, Romford RM3 0BE, Essex, England Harold Wood Hosp Romford Essex England RM3 0BE rd RM3 0BE, Essex, England Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, London SE5 8RX, England Univ London Kings Coll Hosp London England SE5 8RX ndon SE5 8RX, England
Titolo Testata:
PRENATAL DIAGNOSIS
fascicolo: 6, volume: 21, anno: 2001,
pagine: 441 - 444
SICI:
0197-3851(200106)21:6<441:MSLODI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; FREE BETA-HCG; DOWNS-SYNDROME PREGNANCIES; MARKER; GESTATION; SUBUNITS; PROTEIN;
Keywords:
inhibin; trisomy 21; first trimester; aneuploidy; free beta-hCG; PAPP-A; prenatal screening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Spencer, K Harold Wood Hosp, Dept Clin Biochem, Endocrine Unit, Gubbins Lane, RomfordRM3 0BE, Essex, England Harold Wood Hosp Gubbins Lane Romford Essex England RM3 0BE and
Citazione:
K. Spencer et al., "Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester", PRENAT DIAG, 21(6), 2001, pp. 441-444

Abstract

Dimeric inhibin A was measured in maternal serum samples from 45 pregnancies affected by trisomy 21 and 493 samples from unaffected pregnancies at 10-14 weeks of gestation. Inhibin A levels in affected pregnancies were compared with levels of free beta -hCG and PAPP-A in the same series. In the trisomy 21 group, the median multiple of the median (MoM) inhibin A was not significantly elevated (1.28 vs 1.00) with only 15.5% being above the 95th centile. In contrast, the median MoM free beta -hCG was significantly increased (1.05 vs 1.00) with 36% above the 95th centile and PAPP-A was significantly reduced (0.49 vs 1.00) with 42% below the 5th centile. Inhibin A levelsin the trisomy 21 group were significantly correlated with gestational agesuch that median levels rose from 1.04 at 11 weeks to 1.30 at 12 weeks and1.67 at 13 weeks. These findings suggest that first trimester biochemical screening for trisomy 21, which is currently optimised using maternal serumfree beta -hCG and PAPP-A and fetal nuchal translucency, will not benefit from the inclusion of inhibin A. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:28:49