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Titolo:
Between pregnancy biological variability of first trimester markers of Down syndrome: implications for screening in subsequent pregnancies
Autore:
Spencer, K;
Indirizzi:
Harold Wood Hosp, Dept Clin Biochem, Endocrine Unit, Romford RM3 0BE, Essex, England Harold Wood Hosp Romford Essex England RM3 0BE rd RM3 0BE, Essex, England
Titolo Testata:
PRENATAL DIAGNOSIS
fascicolo: 6, volume: 21, anno: 2001,
pagine: 445 - 447
SICI:
0197-3851(200106)21:6<445:BPBVOF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE BETA-HCG; NUCHAL TRANSLUCENCY; GESTATION; RISK;
Keywords:
nuchal translucency; free beta-hCG; PAPP-A; prenatal screening; trisomy 21; counselling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Spencer, K Harold Wood Hosp, Dept Clin Biochem, Endocrine Unit, Gubbins Lane, RomfordRM3 0BE, Essex, England Harold Wood Hosp Gubbins Lane Romford Essex England RM3 0BE and
Citazione:
K. Spencer, "Between pregnancy biological variability of first trimester markers of Down syndrome: implications for screening in subsequent pregnancies", PRENAT DIAG, 21(6), 2001, pp. 445-447

Abstract

In a group of 149 women who had undergone routine first trimester screening using fetal nuchal translucency thickness (NT) and maternal serum free beta -hCG and pregnancy associated plasma protein-A (PAPP-A) in two consecutive pregnancies the within person between pregnancy biological variability of these markers has been assessed. For fetal NT there was no correlation between NT MoM in the first and second pregnancy (r=0.0800). For maternal serum free beta -hCC MoM a significant correlation was observed (r=0.4174) as was also found for PAPP-A MoM (r=0.3270). The implications for such betweenpregnancy marker association is that women who have an increased risk of Down syndrome in their first pregnancy are 1.5-2 times more likely to repeatthis event in their next pregnancy. This observation may be useful in counselling women in the first trimester screening of a subsequent pregnancy. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:12:27