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Titolo:
Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects
Autore:
Shibata, E; Ejima, K; Nanri, H; Toki, N; Koyama, C; Ikeda, M; Kashimura, M;
Indirizzi:
Univ Occupat & Environm Hlth, Dept Hlth Dev, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Dept Obstet & Gynecol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
PLACENTA
fascicolo: 6, volume: 22, anno: 2001,
pagine: 566 - 572
SICI:
0143-4004(200107)22:6<566:EPLOPT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
THIOREDOXIN REDUCTASE; OXIDATIVE STRESS; LIPID-PEROXIDATION; ENDOTHELIAL-CELLS; AMNIOTIC-FLUID; FETAL GROWTH; PREECLAMPSIA; GLUTAREDOXIN; EXPRESSION; CYTOTROPHOBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nanri, H Univ Occupat & Environm Hlth, Dept Hlth Dev, Yahatanishi Ku, Iseigaoka 1-1, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Iseigaoka 1-1 Kitakyushu Fukuoka Japan 8078555
Citazione:
E. Shibata et al., "Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects", PLACENTA, 22(6), 2001, pp. 566-572

Abstract

Recent studies have indicated that pre-eclampsia is closely associated with oxidative stress both in maternal circulation and in the placenta. Protein thiol/disulphide oxidoreductases, such as thioredoxin, glutaredoxin, and protein disulphide isomerase have recently been found to eliminate reactiveoxygen species (ROS) and regenerate oxidatively damaged proteins. Protein thiol/disulphide oxidoreductases ma!; also play; a role in combating pre-eclampsia. In this study, we examined the accumulation of 4-hydroxy-2-nonenal(HNE)-modified proteins, which are markers of lipid peroxidation, in humanplacentae of normal and pre-eclamptic subjects. We also examined the protein levels of thioredoxin, glutaredoxin, and protein disulphide isomerase inplacentae. Immunoblotting and immunohistochemistry showed that HNE-modified proteins accumulated to a greater extent in pre-eclamptic placentae than in normal placentae. In both normal and pre-eclamptic placentae, thioredoxin, glutaredoxin, and protein disulphide isomerase sere detected in the trophoblasts of the floating villi. The levels of these proteins were increasedapproximately; 2- to 3-fold in the pre-eclamptic placentae compared to thenormal placentae. These results indicated that the pre-eclamptic placentaewere exposed to oxidative stress and that the protein thiol/disulphide oxidoreductases were adaptively induced in pre-eclamptic placentae, suggestingpossible roles for thioredoxin, glutaredoxin, and protein disulphide isomerase in protecting placental functions against oxidative stress caused by pre-eclampsia. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:05:14