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Titolo:
Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene
Autore:
Zicha, J; Negrin, CD; Dobesova, Z; Carr, F; Vokurkova, M; McBride, MW; Kunes, J; Dominiczak, AF;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, Ctr Expt Res Cardiovasc Dis, CZ-14220Prague 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 4 20Prague 4, Czech Republic Western Infirm, Gardiner Inst, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland Western Infirm Glasgow Lanark Scotland G11 6NT G11 6NT, Lanark, Scotland
Titolo Testata:
PHYSIOLOGICAL GENOMICS
fascicolo: 2, volume: 6, anno: 2001,
pagine: 99 - 104
SICI:
1094-8341(200107)6:2<99:ANPAAP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; RED-BLOOD-CELLS; SENSITIVE RATS; GLOMERULAR INJURY; NA,K-ATPASE GENE; RESISTANT RATS; SODIUM-PUMP; PRESSURE; TRANSPORT; CHROMOSOME-2;
Keywords:
F-2 hybrids; erythrocyte ion transport; erythrocyte sodium content; plasma cholesterol; rat chromosome 2; alpha(1)-Na+-K+-ATPase gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Zicha, J Acad Sci Czech Republ, Inst Physiol, Ctr Expt Res Cardiovasc Dis,Videnska1083, CZ-14220 Prague 4, Czech Republic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 4 blic
Citazione:
J. Zicha et al., "Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene", PHYSIOL GEN, 6(2), 2001, pp. 99-104

Abstract

A genetic variant of the gene for the alpha (1)-isoform of Na+-K+-ATPase (Atp1a1) was suggested to be involved in the pathogenesis of salt hypertension in Dahl rats through altered Na+:K+ coupling ratio. We studied Na+-K+ pump activity in erythrocytes of Dahl salt-sensitive (SS/Jr) rats in relationto plasma lipids and blood pressure (BP) and the linkage of polymorphic microsatellite marker D2Arb18 (located within intron 1 and exon 2 of Atp1a1 gene) with various phenotypes in 130 SS/Jr x SR/Jr F-2 rats. Salt-hypertensive SS/Jr rats had higher erythrocyte Na 1 content, enhanced ouabain-sensitive (OS) Na+ and Rb+ transport, and higher Na+:Rb+ coupling ratio of the Na+-K+ pump. BP of F-2 hybrids correlated with erythrocyte Na+ content, OS Naextrusion, and OS Na+: Rb+ coupling ratio, but not with OS Rb+ uptake. In F-2 hybrids there was a significant association indicating suggestive linkage (P< 0.005, LOD score 2.5) of an intragenic marker D2Arb18 with pulse pressure but not with mean arterial pressure or any parameter of Na+-K+ pump activity (including its Na+:Rb+ coupling ratio). In contrast, plasma cholesterol, which was elevated in salt-hypertensive Dahl rats and which correlated with BP in F2 hybrids, was also positively associated with OS Na+ extrusion. The abnormal Na+:K+ stoichiometry of the Na+-K+ pump is a consequence of elevated erythrocyte Na+ content and suppressed OS Rb+:K+ exchange. In conclusion, abnormal cholesterol metabolism but not the Atp1a1 gene locus might represent an important factor for both high BP and altered Na+-K+ pump function in salt-hypertensive Dahl rats.

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Documento generato il 21/09/20 alle ore 15:38:43