Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
2-(allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: Role of inhibition of transforming growth factor-beta 1 expression
Autore:
Kang, KW; Ha, JR; Kim, CW; Kim, ND; Kim, SG;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 k Gu, Seoul 151742, South Korea Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Inst, Seoul 151742, South Korea Choong Wae Res Lab, Seoul, South Korea Choong Wae Res Lab Seoul South Korea ng Wae Res Lab, Seoul, South Korea Hanyang Univ, Coll Med, Seoul 133791, South Korea Hanyang Univ Seoul South Korea 133791 oll Med, Seoul 133791, South Korea
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 1, volume: 89, anno: 2001,
pagine: 23 - 29
SICI:
0901-9928(200107)89:1<23:2ACCAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC-FIBROSIS; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; CONCANAVALIN-A; MICE; ACTIVATION; HEPATOTOXICITY; NITROSAMINES; INDUCTION; CIRRHOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SG Seoul Natl Univ, Coll Pharm, Kwanak Gu, Sillim Dong, Seoul 151742,South Korea Seoul Natl Univ Sillim Dong Seoul South Korea 151742 South Korea
Citazione:
K.W. Kang et al., "2-(allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: Role of inhibition of transforming growth factor-beta 1 expression", PHARM TOX, 89(1), 2001, pp. 23-29

Abstract

Exposure to nitrosamines may be the occupational risk factor for liver cirrhosis. 2-(Allylthio)pyrazine, a chemopreventive agent, inhibits CTP2E1 andinduces phase II enzymes. We examined the effects of 2-(allylthio)pyrazineon hepatic fibrosis, a prepathologic state of cirrhosis, and on the expression of transforming growth factor-pr induced by dimethylnitrosamine. Treatment of rats with dimethylnitrosamine for 4 weeks increased plasma alanine/aspartate aminotransferase and gamma -glutamyl transpeptidase activities, and bilirubin content, whereas the total plasma protein and albumin levels were decreased. 2-(Allylthio)pyrazine inhibited dimethylnitrosamine-induced increases in the enzyme activities and bilirubin, and restored the plasma protein and albumin contents. Masson's trichrome staining showed that dimethylnitrosamine induced liver fibrosis, the extent of which was reduced by 2-(allylthio)pyrazine treatments. Reverse transcription-polymerase chain reaction analysis revealed that 2-(allylthio)pyrazine inhibited production of transforming growth factor-beta1 mRNA by dimethylnitrosamine. These results demonstrated that 2-(allylthio)pyrazine might inhibit dimethylnitrosamine-induced liver fibrosis due to suppression of CYP2E1 expression and transforming growth factor-beta1 production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:02:53