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Titolo:
The endocannabinoid nervous system: unique opportunities for therapeutic intervention
Autore:
Porter, AC; Felder, CC;
Indirizzi:
Eli Lilly & Co, Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 osci, Indianapolis, IN 46285 USA
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 1, volume: 90, anno: 2001,
pagine: 45 - 60
SICI:
0163-7258(200104)90:1<45:TENSUO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID AMIDE HYDROLASE; CANNABINOID CB1 RECEPTORS; MEDIATED SIGNAL-TRANSDUCTION; RAT HIPPOCAMPAL-NEURONS; SINGLE AMINO-ACID; INHIBIT N-TYPE; ANANDAMIDE AMIDOHYDROLASE; INVERSE AGONIST; MOLECULAR CHARACTERIZATION; ENZYMATIC-SYNTHESIS;
Keywords:
cannabinoid; anandamide; fatty acid amidohydrolase; allosteric modulator;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
183
Recensione:
Indirizzi per estratti:
Indirizzo: Felder, CC Eli Lilly & Co, Lilly Res Labs, Div Neurosci, Drop 0510, Indianapolis, IN 46285 USA Eli Lilly & Co Drop 0510 Indianapolis IN USA 46285 IN 46285 USA
Citazione:
A.C. Porter e C.C. Felder, "The endocannabinoid nervous system: unique opportunities for therapeutic intervention", PHARM THERA, 90(1), 2001, pp. 45-60

Abstract

The active principle in marijuana, Delta (9)-tetrahydrocannabinol (THC), has been shown to have wide therapeutic application for a number of important medical conditions, including pain, anxiety, glaucoma, nausea, emesis, muscle spasms, and wasting diseases. Delta (9)-THC binds to and activates twoknown cannabinoid receptors found in mammalian tissue, CB1 and CB2. The development of cannabinoid-based therapeutics has focused predominantly on the CBI receptor, based on its predominant and abundant localization in the CNS. Like most of the known cannabinoid agonists, Delta (9)-THC is lipophilic and relatively nonselective for both receptor subtypes. Clinical studies show that nonselective cannabinoid agonists are relatively safe and providetherapeutic efficacy, but that they also induce psychotropic side effects. Recent studies of the biosynthesis, release, transport, and disposition ofanandamide are beginning to provide an understanding of the role of lipid transmitters in the CNS. This review attempts to link current understandingof the basic biology of the endocannabinoid nervous system to novel opportunities for therapeutic intervention. This new knowledge may facilitate thedevelopment of cannabinoid receptor-targeted therapeutics with improved safety and efficacy profiles. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:31:25