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Titolo:
MDMA ('ecstasy') exhibits an anxiogenic-like activity in social encountersbetween male mice
Autore:
Maldonado, E; Navarro, JF;
Indirizzi:
Univ Malaga, Fac Psychol, Dept Psychobiol, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 Dept Psychobiol, E-29071 Malaga, Spain
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 1, volume: 44, anno: 2001,
pagine: 27 - 31
SICI:
1043-6618(200107)44:1<27:M(EAAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; ANIMAL-MODELS; 3,4-METHYLENEDIOXY-METHAMPHETAMINE MDMA; AGONISTIC ENCOUNTERS; RECREATIONAL USE; ANXIETY; PROFILE; PHARMACOLOGY; AMPHETAMINE; SEROTONIN;
Keywords:
MDMA; aggression; anxiety; FG 7142; social encounters; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Navarro, JF Univ Malaga, Fac Psychol, Dept Psychobiol, Campus Teatinos, E-29071 Malaga, Spain Univ Malaga Campus Teatinos Malaga Spain E-29071 alaga, Spain
Citazione:
E. Maldonado e J.F. Navarro, "MDMA ('ecstasy') exhibits an anxiogenic-like activity in social encountersbetween male mice", PHARMAC RES, 44(1), 2001, pp. 27-31

Abstract

Recent studies have suggested that 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy'), a synthetic amphetamine derivative, might exhibit an anxiogenic-like activity in rodents. In this work, we examined the effects of MDMA (1, 8 and 15 mg kg(-1), i.p.) on social encounters between male mice using an ethopharmacological approach. Likewise, we compared the behavioural profile of MDMA with that induced by FG 7142 (15 mg kg(-1), i.p.), an anxiogenic benzodiazepine receptor ligand. Individually housed mice were exposed to anosmic standard opponents 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. MDMA (8 and 15 mg kg(-1)) produced a behavioural pattern characterized by a marked decrease of aggression (threat and attack) as well as social investigation, body care and digging behaviours, without affecting immobility. Moreover, avoidance/flee and defence/submission behaviours were significantly increased by the drug. A very similar behavioural profile was observed in FC 7142-treated animals. Overall, these findings might indicate that MDMA has anxiogenic-like properties in male mice. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:52:42