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Titolo:
The effects of acute melatonin and ethanol treatment on antioxidant enzymeactivities in rat testes
Autore:
Oner-Iyidogan, Y; Gurdol, F; Oner, P;
Indirizzi:
Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 iochem, TR-34390 Istanbul, Turkey
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 2, volume: 44, anno: 2001,
pagine: 89 - 93
SICI:
1043-6618(200108)44:2<89:TEOAMA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; GLUTATHIONE-PEROXIDASE; ALCOHOL-INTOXICATION; SUPEROXIDE-DISMUTASE; TESTOSTERONE LEVELS; OXIDATIVE STRESS; LEYDIG-CELLS; INHIBITION; LIVER; DETOXIFICATION;
Keywords:
melatonin; lipid peroxidation; ethanol; testes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Gurdol, F Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 -34390 Istanbul, Turkey
Citazione:
Y. Oner-Iyidogan et al., "The effects of acute melatonin and ethanol treatment on antioxidant enzymeactivities in rat testes", PHARMAC RES, 44(2), 2001, pp. 89-93

Abstract

The pineal hormone melatonin (N-acetyl, 5-methoxytryptamine) was recently accepted to act as an antioxidant under both in vivo and in vitro conditions. In this study, we examined the possible preventive effect of melatonin on ethanol-induced lipid peroxidation in rat testes. Thirty-seven male Wistar albino rats, 5.5-6 months old, were randomly divided into four groups (9-10 animals in each). The first group (control animals) received 4% ethanol at similar intervals to the experimental groups to equalize the stress effect. The second group received only melatonin i.p. 7 mg kg(-1) bw three times over 1.5 h intervals. The third group received only 30% alcohol 3 g kg(-1) bw twice daily. The fourth group were treated with melatonin and ethanol according to the above protocole, melatonin injections preceeding ethanol treatments. The product of lipid peroxidation, malondialdehyde (MDA) and antioxidant enzymes, superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured in the post-mitochondrial fraction of the testes. MDA levels were significantly increased due to acute ethanol intoxication. GPx activity was higher in the three experimental groups thanthe control levels. The activity of CAT was increased significantly in themelatonin plus ethanol-treated group but the other groups appeared not to be influenced by acute ethanol treatment. Cu-Zn SOD activity remained unaltered. These results suggest that antioxidants may be a protective agent forthe testicular injury caused by ethanol consumption. (C) 2001 Academic Press.

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Documento generato il 07/04/20 alle ore 22:47:26