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Titolo:
Effects of peritoneal dialysis with an overnight icodextrin dwell on parameters of glucose and lipid metabolism
Autore:
Bredie, SJH; Bosch, FH; Demacker, PNM; Stalenhoef, AFH; van Leusen, R;
Indirizzi:
Univ Med Ctr Nijmegen, Dept Med, Div Gen Internal Med, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr Nijmegen Nijmegen Netherlands NL-6500 HB megen, Netherlands Rijnstate Hosp, Dept Internal Med, Arnhem, Netherlands Rijnstate Hosp Arnhem Netherlands ept Internal Med, Arnhem, Netherlands
Titolo Testata:
PERITONEAL DIALYSIS INTERNATIONAL
fascicolo: 3, volume: 21, anno: 2001,
pagine: 275 - 281
SICI:
0896-8608(200105/06)21:3<275:EOPDWA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN SUBFRACTION; CORONARY HEART-DISEASE; FREE FATTY-ACIDS; INHERITED SUSCEPTIBILITY; ENHANCED SUSCEPTIBILITY; INVITRO OXIDATION; HEALTHY-SUBJECTS; RENAL-FAILURE; INSULIN; CHOLESTEROL;
Keywords:
atherogenic lipoprotein profile; icodextrin; glucose; lipoproteins; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bredie, SJH Univ Med Ctr Nijmegen, Dept Med, Div Gen Internal Med, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr Nijmegen POB 9101 Nijmegen Netherlands NL-6500 HB
Citazione:
S.J.H. Bredie et al., "Effects of peritoneal dialysis with an overnight icodextrin dwell on parameters of glucose and lipid metabolism", PERIT DIA I, 21(3), 2001, pp. 275-281

Abstract

. Objective: To examine whether a reduced daily glucose load by overnight application of the less-absorbed glucose polymer icodextrin would have favorable effects on lipid profiles of continuous ambulatory peritoneal dialysis (CAPD) patients.. Study Design: Randomized crossover study with two subsequent periods of 6 weeks.. Setting: Home PD unit of a secondary-care hospital..Patients: Twenty-one nondiabetic CAPD patients (15 male, 6 female; mean age 50.3 +/- 11.8 years). . intervention: Participants were randomly assigned to receive an overnight dwell with either standard glucose solution or with a 7.5% icodextrin-containing solution..Main Outcome Measures: Relation between reduction in the total amount of intraperitoneal infused glucose and parameters of glucose (plasma glucose, insulin, and HbA(1C)) and lipid metabolism [free fatty acids, plasma lipids, lipoproteins, and low density lipoprotein (LDL) subfraction profile].. Results: After the icodextrin dwells, a reduction of plasma total cholesterol (from 5.43 +/- 0.85 to 4.86 +/- 0.70 mmol/L, p< 0.001) and LDL cholesterol (from 3.38 +/- 0.87 to 2.93 +/- 0.73 mmol/L, p = 0.001) was observed. Also, high density lipoprotein (HDL) cholesterol (from 0.95 +/- 0.27 to 0.90 +/- 0.24 mmol/L, p = 0.029) was reduced, but the plasma total cholesterol-to-HDL ratio remained similar. Plasma free fatty acids and triglyceride levels tended to decrease (from 0.16 +/- 0.10 to 0.13 +/- 0.08 mmol/L, p 0.06, and from 2.14 +/- 1.96 to 1.92 +/- 1.03 mmol/L, respectively). Evaluation of LDL subfraction profiles after ultracentrifugation showed a more buoyant LDL subfraction profile with fewer dense LDL particles in 6 patients andno changes in 14 patients after icodextrin. The effects on lipids were notaccompanied by a decrease in fasting plasma glucose (from 5.76 +/- 1.29 to5.86 +/- 0.80 mmol/L) or insulin levels (from 19.5 +/- 14.4 to 20.3 +/- 13.0 mU/L).. Conclusion: These results suggest a beneficial effect on lipid profiles of CAPD patients with the use of an overnight dwell with icodextrin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:37:05