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Titolo:
OLETF (Otsuka Long-Evans Tokushima Fatty) rats that lack the CCK 1 (A) receptor develop less behavioral sensitization to repeated cocaine treatment than wild type LETO (Long Evans Tokushima Otsuka) rats
Autore:
Beinfeld, MC; Connolly, K; Pierce, RC;
Indirizzi:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ Boston MA USA 02111 col & Expt Therapeut, Boston, MA 02111 USA Boston Univ, Sch Med, Dept Pharmacol & Psychiat, Lab Neuropsychopharmacol,Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Neuropsychopharmacol,Boston, MA 02118 USA
Titolo Testata:
PEPTIDES
fascicolo: 8, volume: 22, anno: 2001,
pagine: 1285 - 1290
SICI:
0196-9781(200108)22:8<1285:O(LTFR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ (CCK)-A RECEPTOR; NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; TIME COURSE; AMPHETAMINE; EXPRESSION; GENE; CORTEX; TRANSMISSION; ACQUISITION;
Keywords:
CCK; CCK 1 receptor; OLETF rat; cocaine sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Beinfeld, MC Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 MA 02111 USA
Citazione:
M.C. Beinfeld et al., "OLETF (Otsuka Long-Evans Tokushima Fatty) rats that lack the CCK 1 (A) receptor develop less behavioral sensitization to repeated cocaine treatment than wild type LETO (Long Evans Tokushima Otsuka) rats", PEPTIDES, 22(8), 2001, pp. 1285-1290

Abstract

OLETF (Otsuka Long-Evens Tokushima Fatty) lacking the CCK 1 (A) receptor have similar spontaneous activity and locomotor response (horizontal and vertical activity) in response to a single injection of cocaine as the wild type LETO (Long Evans Tokushima Otsuka) rats. In contrast, the OLETF rats display more stereotypy in response to the first dose of cocaine than the LETOrats. Tested at 7 and 14 days after a one week daily treatment with cocaine, the LETO rats display robust behavioral sensitization to cocaine while the OLETF rats did not. These results support the hypothesis that endogenousCCK released by cocaine treatment and acting at CCK 1 receptors is required for the development and/or expression of this behavior. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:16:18