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Titolo:
Inflammation and remodeling in the adult and child with asthma
Autore:
Jeffery, P;
Indirizzi:
Royal Brompton Hosp, Imperial Hosp, Sch Med, Dept Gene Therapy, London SW36NP, England Royal Brompton Hosp London England SW3 6NP erapy, London SW36NP, England
Titolo Testata:
PEDIATRIC PULMONOLOGY
, , anno: 2001, supplemento:, 21
pagine: 3 - 16
SICI:
8755-6863(2001):<3:IARITA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY SMOOTH-MUSCLE; BRONCHOALVEOLAR LAVAGE FLUID; NEWLY DIAGNOSED ASTHMA; CHRONIC LUNG-DISEASE; BRONCHIAL BIOPSIES; ATOPIC ASTHMA; FATAL ASTHMA; CYSTEINYL LEUKOTRIENES; MUCOSAL INFLAMMATION; CONTROLLED TRIAL;
Keywords:
asthma; inflammation; remodeling; leukotriene receptor antagonists; pathology; biopsy; children; corticosteroids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Jeffery, P Royal Brompton Hosp, Imperial Hosp, Sch Med, Dept Gene Therapy,Sydney St,London SW3 6NP, England Royal Brompton Hosp Sydney St London England SW3 6NP , England
Citazione:
P. Jeffery, "Inflammation and remodeling in the adult and child with asthma", PEDIAT PULM, 2001, pp. 3-16

Abstract

Inflammation and remodeling are characteristic features of the conducting airways in asthma, but the relationships between inflammation, inappropriate remodeling, bronchial hyperresponsiveness, and reduced pulmonary functionare still unclear. In both adults and children with asthma, there are structural changes of the conducting airways that include injury and loss of the surface epithelium, thickening of the reticular basement membrane, increases of underlying collagen, blood vessels, and airway smooth muscle, and plugging of the airways by exudate. Bronchial biopsies obtained from persons with mild stable asthma already demonstrate the presence of inflammation. Many of the inflammatory and structural changes begin early in childhood. Whereas corticosteroids markedly reduce many aspects of inflammation, it is not known whether and how they affect the changes associated with airway wall remodeling. Leukotriene receptor antagonists appear to be antiinflammatory and able to reduce the proliferation of bronchial smooth muscle. (C) 2001Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:15:55