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Titolo:
Small round cell tumor with biphenotypic differentiation and variant of t(21;22)(q22;q12)
Autore:
Tan, SY; Burchill, S; Brownhill, SC; Gerrard, MP; Watmore, A; Wagner, BE; Variend, S;
Indirizzi:
Childrens Hosp, Dept Pathol Cytogenet & Oncol, Sheffield S10 2TH, S Yorkshire, England Childrens Hosp Sheffield S Yorkshire England S10 2TH S Yorkshire, England No Gen Hosp, Dept Pathol, Sheffield S10 2TH, S Yorkshire, England No Gen Hosp Sheffield S Yorkshire England S10 2TH H, S Yorkshire, England St James Univ Hosp, Candlelighters Childrens Canc Res Lab, Leeds LS9 7TF, W Yorkshire, England St James Univ Hosp Leeds W Yorkshire England LS9 7TF W Yorkshire, England
Titolo Testata:
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
fascicolo: 4, volume: 4, anno: 2001,
pagine: 391 - 396
SICI:
1093-5266(200107/08)4:4<391:SRCTWB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE FUSION; EWINGS-SARCOMA; SOLID TUMORS; DIAGNOSIS; EWS; TRANSLOCATIONS; TRANSCRIPTS;
Keywords:
EWS-ERG; differentiation; biphenotypic; small round cell tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Variend, S Childrens Hosp, Dept Pathol Cytogenet & Oncol, Western Bank, Sheffield S102TH, S Yorkshire, England Childrens Hosp Western Bank Sheffield S Yorkshire England S10 2TH
Citazione:
S.Y. Tan et al., "Small round cell tumor with biphenotypic differentiation and variant of t(21;22)(q22;q12)", PEDIATR D P, 4(4), 2001, pp. 391-396

Abstract

A 14-year-old boy presented with a soft tissue swelling on the outer aspect of his left upper arm. Examination of the tumor by light microscopy showed a small round cell tumor with a rare focus of myogenic differentiation. Myogenic differentiation was confirmed on ultrastructural examination by immunohistochemistry and reverse transcriptase polymerase chain reaction (RT-PCR). Conventional G-banding and fluorescent in situ hybridization (FISH) demonstrated a complex variant of t(21; 22)(q22;q12). By RT-PCR, the EWS-ERG fusion transcript was defined as type 9e. This tumor was unusual in that itshowed characteristics of myogenic and neural differentiation, and contained a rearrangement of the EWS gene consistent with a diagnosis of Ewing's sarcoma. This supports the hypothesis that a class of biphenotypic childhoodsarcomas, with features of myogenic and neural differentiation, exists that may be related to the Ewing's sarcoma family of tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 17:06:36