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Titolo:
Origin of cardiac mucosa: Ontogenic consideration
Autore:
Zhou, H; Greco, MA; Daum, F; Kahn, E;
Indirizzi:
NYU, Sch Med, N Shore Univ Hosp, Dept Pathol, Manhasset, NY 11030 USA NYUManhasset NY USA 11030 niv Hosp, Dept Pathol, Manhasset, NY 11030 USA NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA NYU New York NY USA 10016 U, Med Ctr, Dept Pathol, New York, NY 10016 USA Kaplan Comprehens Canc Ctr, New York, NY 10016 USA Kaplan Comprehens Canc Ctr New York NY USA 10016 , New York, NY 10016 USA NYU, Sch Med, Dept Pediat, Div Pediat Gastroenterol, Manhasset, NY 11030 USA NYU Manhasset NY USA 11030 Pediat Gastroenterol, Manhasset, NY 11030 USA
Titolo Testata:
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
fascicolo: 4, volume: 4, anno: 2001,
pagine: 358 - 363
SICI:
1093-5266(200107/08)4:4<358:OOCMOC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX DISEASE; INTESTINAL METAPLASIA; BARRETTS-ESOPHAGUS; GASTRIC CARDIA; JUNCTION; INFLAMMATION;
Keywords:
anatomy and histology; growth and development; gastric mucosa; cardiac glands; gastric glands; esophagogastric junction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kahn, E NYU, Sch Med, N Shore Univ Hosp, Dept Pathol, 300 Community Dr, Manhasset,NY 11030 USA NYU 300 Community Dr Manhasset NY USA 11030 Manhasset,NY 11030 USA
Citazione:
H. Zhou et al., "Origin of cardiac mucosa: Ontogenic consideration", PEDIATR D P, 4(4), 2001, pp. 358-363

Abstract

The origin and histology of the cardiac mucosa remains controversial. The classical concept that the cardiac mucosa is of gastric origin has been challenged by those who advocate that the cardiac mucosa results from a metaplastic esophageal process. Some regard cardiac mucosa as consisting solely of pure mucous glands, whereas others accept the presence of isolated parietal cells within the mucous gland (mixed glands). In this study, we have clarified the presence and site of origin of the cardiac mucosa and its histological composition. To do so we studied the microscopic characteristics of the gastric side of the squamous-columnar junction (SCJ) of 77 autopsied fetuses of different gestational ages (prenatal group) and of infants, young children, and adolescents (postnatal group). We evaluated the presence or absence of a transitional zone, defined as the area between the squamous esophageal and oxyntic mucosa, the glandular composition of the transitional zone (i.e., pure mucous and mixed glands), and the presence or absence of inflammation. Our study revealed that a transitional zone with the microscopic characteristics of cardiac mucosa was universally present at the SCJ. Themicroscopic characteristics of this zone varied with age. Both pure mucousand mixed glands were observed. We conclude that the cardiac mucosa is partially if not entirely the result of normal embryonic gastric development. Both mucous and mixed glands constitute normal components of the cardiac mucose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:52:15