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Titolo:
Pharmacokinetics and analgesic effect of ropivacaine following ilioinguinal/iliohypogastric nerve block in children.
Autore:
Dalens, B; Ecoffey, C; Joly, A; Giaufre, E; Gustafsson, U; Huledal, G; Larsson, LE;
Indirizzi:
AstraZeneca R&D, Clin Operat, Clin R&D, SE-15185 Sodertalje, Sweden AstraZeneca R&D Sodertalje Sweden SE-15185 , SE-15185 Sodertalje, Sweden Pontchaillou Hosp, Rennes, France Pontchaillou Hosp Rennes FrancePontchaillou Hosp, Rennes, France Hotel Dieu Hosp, Dept Anaesthesia & Intens Care, Clermont Ferrand, France Hotel Dieu Hosp Clermont Ferrand France Care, Clermont Ferrand, France St Joseph Hosp, Marseille, France St Joseph Hosp Marseille FranceSt Joseph Hosp, Marseille, France
Titolo Testata:
PAEDIATRIC ANAESTHESIA
fascicolo: 4, volume: 11, anno: 2001,
pagine: 415 - 420
SICI:
1155-5645(200107)11:4<415:PAAEOR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAUDAL BLOCK; ALPHA-1-ACID GLYCOPROTEIN; POSTOPERATIVE ANALGESIA; HERNIA REPAIR; BUPIVACAINE; PAIN; CHROMATOGRAPHY; BINDING; PLASMA;
Keywords:
ropivacaine; ilioinguinal/iliohypogastric nerve block; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gustafsson, U AstraZeneca R&D, Clin Operat, Clin R&D, SE-15185 Sodertalje,Sweden AstraZeneca R&D Sodertalje Sweden SE-15185 ertalje, Sweden
Citazione:
B. Dalens et al., "Pharmacokinetics and analgesic effect of ropivacaine following ilioinguinal/iliohypogastric nerve block in children.", PAEDIATR AN, 11(4), 2001, pp. 415-420

Abstract

Background: The aim was to investigate the efficacy, tolerance and pharmacokinetics of ropivavcaine when administered for ilioinguinal/iliohypogastric block in children. Methods: We examined the pharmacokinetics and analgesic efficacy after ilioinguinal/iliohypogastric nerve block with 3 mg.kg(-1) ropivacaine 5 mg.ml(-1) in 22 children, aged 1-12 years, who were scheduled for inguinal surgery. Sixteen of 22 patients had a postoperative pain score < 4 (Objective Pain Scale). Nine children were given supplementary analgesics during the first six postoperative hours. Results: The peak plasma concentration of total ropivacaine was 1.50 +/- 0.93 mg.l(-1) (mean +/- SD) (range 0.64-4.77 mg.l(-1)) 15-64 min after the injection. The peak plasma concentration of free ropivacaine was 0.05 +/- 0.03 mg.l(-1) (0.02-0.14 mg.l(-1)), which is well below the threshold for toxicity in adults. The terminal half-life was 2.0 +/- 0.7 h. No safety concerns or symptoms suggestive of systemic toxicity were observed. Conclusions: A dose of 3 mg.kg(-1) of ropivacaine given as a single ilioinguinal/iliohypogastric nerve block in 1-12-year-old children provides satisfactory postoperative pain relief, and is well tolerated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:23:49