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Titolo:
Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis
Autore:
Kozaki, K; Koshikawa, K; Tatematsu, Y; Miyaishi, O; Saito, H; Hida, T; Osada, H; Takahashi, T;
Indirizzi:
Aichi Canc Ctr, Res Inst, Div Mol Oncol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Hosp, Dept Internal Med, Nagoya, Aichi 4648681, Japan AichiCanc Ctr Hosp Nagoya Aichi Japan 4648681 goya, Aichi 4648681, Japan Natl Inst Longev Sci, Dept Basic Gerontol, Aichi 4748522, Japan Natl Inst Longev Sci Aichi Japan 4748522 Gerontol, Aichi 4748522, Japan
Titolo Testata:
ONCOGENE
fascicolo: 31, volume: 20, anno: 2001,
pagine: 4228 - 4234
SICI:
0950-9232(20010712)20:31<4228:MAOAHM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; ADENOCARCINOMAS; CHEMOKINES;
Keywords:
human lung cancer; metastasis; invasion; expression profiling; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Aichi Canc Ctr, Res Inst, Div Mol Oncol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 chi 4648681, Japan
Citazione:
K. Kozaki et al., "Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis", ONCOGENE, 20(31), 2001, pp. 4228-4234

Abstract

This study established and characterized low-metastatic revertant and parental clones of a highly metastatic human lung cancer cell line, NCI-H460-LNM35 (hereafter referred to as LNM35), Expression-profiling analysis revealed that up-regulation of various proinflammatory cytokines and angiogenic chemotactic chemokines was present in LNM35, Further, while COX-2 itself is known to be inducible in inflammation, COX-2 expression levels correlated well with the capabilities of these clones for not only in vitro motility andinvasion but also in vivo metastasis, and COX-2 inhibitors were shown for the first time to reduce lung cancer metastasis in vivo. These findings suggest that lung cancer cells may mimic inflammatory cells in the process of metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:05:07