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Titolo:
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
Autore:
Mende, I; Malstrom, S; Tsichlis, PN; Vogt, PK; Aoki, M;
Indirizzi:
Scripps Clin & Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Med, La Jolla, CA 92037 USA Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
ONCOGENE
fascicolo: 32, volume: 20, anno: 2001,
pagine: 4419 - 4423
SICI:
0950-9232(20010719)20:32<4419:OTIBMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-B; HUMAN PANCREATIC-CANCER; PHOSPHOINOSITIDE 3-KINASE; MOLECULAR-CLONING; PHOSPHATIDYLINOSITOL 3-KINASE; CATALYTIC SUBUNIT; TUMOR SUPPRESSION; TRANSGENIC MICE; ACTIVATION; PHOSPHORYLATION;
Keywords:
Akt; transformation; serine/threonine kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Vogt, PK 10550 N Torrey Pines Rd,BCC-239, La Jolla, CA 92037 USA 10550 N Torrey Pines Rd,BCC-239 La Jolla CA USA 92037 92037 USA
Citazione:
I. Mende et al., "Oncogenic transformation induced by membrane-targeted Akt2 and Akt3", ONCOGENE, 20(32), 2001, pp. 4419-4423

Abstract

The kinases Akt2, Akt3 and their myristylated variants, Myr-Akt2 and Myr-Akt3 were expressed by the RCAS vector in chicken embryo fibroblasts (CEF), Myr-Akt2 and Myr-Akt3 were strongly oncogenic, inducing multilayered foci of transformed cells. In contrast, wild-type Akt2 and Akt3 were only poorly transforming, their efficiencies of focus formation were more than 100-foldlower; foci appeared later and showed less multilayering, Addition of the myristylation signal not only enhanced oncogenic potential hut also increased kinase activities. Myr-Akt2 and Myr-Akt3 also induced hemangiosarcomas in the animal, whereas wild type Akt2 and Akt3 were not oncogenic in vivo. Furthermore, Akt2, driven by the lck (lymphocyte specific kinase) promoter in transgenic mice, induced lymphomas, The oncogenic effects of Akt2 and Akt3 described here are indistinguishable from those of Akt1, The downstream targets relevant to oncogenic transformation are therefore probably shared by the three Akt kinases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:16:11