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Titolo:
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice
Autore:
Weil, MM; Kittrell, FS; Yu, YJ; McCarthy, M; Zabriskie, RC; Ullrich, RL;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Expt Radiat Oncol, Houston, TX 77030 USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Cell Biol, Houston, TX 77030 USA Univ Texas, Med Branch, Dept Radiat Oncol, Div Biol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 ncol, Div Biol, Galveston, TX 77555 USA Colorado State Univ, Dept Radiol Hlth Sci, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Sci, Ft Collins, CO 80523 USA
Titolo Testata:
ONCOGENE
fascicolo: 32, volume: 20, anno: 2001,
pagine: 4409 - 4411
SICI:
0950-9232(20010719)20:32<4409:RIGIAM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATAXIA-TELANGIECTASIA; DEFICIENT MICE; CANCER; SENSITIVITY; BALB/C;
Keywords:
radiation effects; breast cancer; ataxia-telangiectasia; genomic instability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Weil, MM Univ Texas, MD Anderson Canc Ctr, Dept Expt Radiat Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TXUSA 77030 , TX 77030 USA
Citazione:
M.M. Weil et al., "Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice", ONCOGENE, 20(32), 2001, pp. 4409-4411

Abstract

Ataxia-telangiectasia (AT) is a genetic syndrome resulting from the inheritance of two defective copies of the ATM gene that includes among its stigmata radiosensitivity and cancer susceptibility. Epidemiological studies have demonstrated that although women with a single defective copy of ATM (AT heterozygotes) appear clinically normal, they may never the less have an increased relative risk of developing breast cancer. Whether they are at increased risk for radiation-induced breast cancer from medical exposures to ionizing radiation is unknown. We have used a murine model of AT to investigate the effect of a single defective Atm allele, the murine homologue of ATM, on the susceptibility of mammary epithelial cells to radiation-induced transformation. Here we report that mammary epithelial cells from irradiated mice with one copy of Atm truncated in the PI-3 kinase domain were susceptible to radiation-induced genomic instability and generated a 10% incidence of dysplastic mammary ducts when transplanted into syngenic recipients, whereas cells from Atm(+/+) mice were stable and formed only normal ducts. Since radiation-induced ductal dysplasia is a precursor to mammary cancer, theresults indicate that AT heterozygosity increases susceptibility to radiogenic breast cancer in this murine model system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:22:55