Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
Autore:
Vieira, HLA; Belzacq, AS; Haouzi, D; Bernassola, F; Cohen, I; Jacotot, E; Ferri, KF; El Hamel, C; Bartle, LM; Melino, G; Brenner, C; Goldmacher, V; Kroemer, G;
Indirizzi:
Inst Gustave Roussy, CNRS, UMR1599, F-94805 Villejuif, France Inst GustaveRoussy Villejuif France F-94805 , F-94805 Villejuif, France Univ Technol Compiegne, CNRS, UMR6022, F-60205 Compiegne, France Univ Technol Compiegne Compiegne France F-60205 -60205 Compiegne, France Univ Roma Tor Vergata, Biochem Lab, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 iochem Lab, I-00133 Rome, Italy Apoptosis Technol Inc, Cambridge, MA 02139 USA Apoptosis Technol Inc Cambridge MA USA 02139 Inc, Cambridge, MA 02139 USA
Titolo Testata:
ONCOGENE
fascicolo: 32, volume: 20, anno: 2001,
pagine: 4305 - 4316
SICI:
0950-9232(20010719)20:32<4305:TANTAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY TRANSITION PORE; DEPENDENT ANION CHANNEL; CYTOCHROME-C RELEASE; MITOCHONDRIAL ADP/ATP CARRIER; CELL-DEATH; INDUCED APOPTOSIS; CYCLOPHILIN-D; BCL-2; BAX; PROTEINS;
Keywords:
apoptosis; Bcl-2; (V)MIA; mitochondria; permeability transition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Kroemer, G Inst Gustave Roussy, CNRS, UMR1599, Pavillon Rech 1,39 Rue Camille Desmoulins, F-94805 Villejuif, France Inst Gustave Roussy Pavillon Rech1,39 Rue Camille Desmoulins Villejuif France F-94805
Citazione:
H.L.A. Vieira et al., "The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal", ONCOGENE, 20(32), 2001, pp. 4305-4316

Abstract

Nitric oxide (NO), peroxynitrite, and 4-hydroxynonenal (HNE) may be involved in the pathological demise of cells via apoptosis, Apoptosis induced by these agents is inhibited by Bcl-2, suggesting the involvement of mitochondria in the death pathway. In vitro, NO, peroxynitrite and HNE can cause direct permeabilization of mitochondrial membranes, and this effect is inhibited by cyclosporin A, indicating involvement of the permeability transition pore complex (PTPC) in the permeabilization event. NO, peroxynitrite and HNE also permeabilize proteoliposomes containing the adenine nucleotide translocator (ANT), one of the key components of the PTPC, yet have no or littleeffects on protein-free control liposomes, ANT-dependent, NO-, peroxynitrite- or HNE-induced permeabilization is at least partially inhibited by recombinant Bcl-2 protein, as well as the antioxidants trolox and butylated hydroxytoluene, In vitro, none of the tested agents (NO, peroxynitrite, FINE, and tert-butylhydroperoxide) causes preferential carbonylation HNE adduction, or nitrotyrosylation of ANT. How ever, all these agents induced ANT to undergo thiol oxidation/derivatization. Peroxynitrite and HNE also caused significant lipid peroxidation, which was antagonized by butylated hydroxytoluene but not by recombinant Bcl-2, Transfection-enforced expression of vMIA, a viral apoptosis inhibitor specifically targeted to ANT, largely reducesthe mitochondrial and nuclear signs of apoptosis induced by NO, peroxynitrite and HNE in intact cells. Taken together these data suggest that NO, peroxynitrite, and HNE may directly act on ANT to induce mitochondrial membrane permeabilization and apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:09:58