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Titolo:
Trehalose suppresses lipopolysaccharide-induced osteoclastogenesis bone marrow in mice
Autore:
Arai, C; Kohguchi, M; Akamatsu, S; Arai, N; Yoshizane, C; Hasegawa, N; Hanaya, T; Arai, S; Ikeda, M; Kurimoto, M;
Indirizzi:
Hayashibara Biochem Labs Inc, Fujisaki Inst, Okayama 7028006, Japan Hayashibara Biochem Labs Inc Okayama Japan 7028006 kayama 7028006, Japan
Titolo Testata:
NUTRITION RESEARCH
fascicolo: 7, volume: 21, anno: 2001,
pagine: 993 - 999
SICI:
0271-5317(200107)21:7<993:TSLOBM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; OVARIECTOMIZED MICE; INTERLEUKIN-6 PRODUCTION; RESORPTION; MACROPHAGES; RECEPTOR; CELLS;
Keywords:
trehalose; lipopolysaccharide; tumor necrosis factor-alpha; bone resorption; osteoclast; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, C Hayashibara Biochem Labs Inc, Fujisaki Inst, 675-1 Fujisaki, Okayama 7028006, Japan Hayashibara Biochem Labs Inc 675-1 Fujisaki Okayama Japan 7028006
Citazione:
C. Arai et al., "Trehalose suppresses lipopolysaccharide-induced osteoclastogenesis bone marrow in mice", NUTR RES, 21(7), 2001, pp. 993-999

Abstract

We have previously shown that trehalose suppresses bone loss in ovariectomized (OVX) mice by way of inhibiting osteoclast differentiation in bone marrow. Also, trehalose inhibits the secretion of interleukin-6 in bone marrowcell cultures, resulting in a decrease in osteoclast formation. In this study, we examined the effect of trehalose on osteoclastogenesis using another model of bone resorption, namely lipopolysaccharide (LPS)-stimulated osteoclast induction. Mice were given trehalose (1g/kg) by gastric intubation for 5 consecutive days, and 24 hours later, 14 mg/kg of LPS was injected intraperitoneally. Trehalose significantly suppressed LPS-induced tumor necrosis factor (TNF)-alpha production after 90 min and decreased the number of osteoclasts in the bone marrow 48 hours after LPS injection. These results indicate that trehalose suppresses excessive osteoclastogenesis not only in OVX mice but also in a LPS-induced bone resorption mouse model and further suggest that the latter finding may be mediated at least in part through a decrease in TNF-alpha production. (C) 2001 Elsevier Science Inc. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:28:29