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Titolo:
Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of 7-substituted isothiazolo[4,5-d]pyrimidine C-nucleosides
Autore:
Wamhoff, H; Bamberg, A; Sohar, P;
Indirizzi:
Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany Univ Bonn Bonn Germany D-53121 gan Chem & Biochem, D-53121 Bonn, Germany Lorand Eotvos Univ, Inst Inorgan & Gen Chem, H-1117 Budapest, Hungary Lorand Eotvos Univ Budapest Hungary H-1117 hem, H-1117 Budapest, Hungary
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 3, volume: 20, anno: 2001,
pagine: 229 - 241
SICI:
1525-7770(2001)20:3<229:ESOFIC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-HIV ACTIVITY; DERIVATIVES; OLIGONUCLEOTIDES; ANALOGS; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wamhoff, H Univ Bonn, Kekule Inst Organ Chem & Biochem, Gerhard Domagk Str1, D-53121Bonn, Germany Univ Bonn Gerhard Domagk Str 1 Bonn Germany D-53121 n, Germany
Citazione:
H. Wamhoff et al., "Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of 7-substituted isothiazolo[4,5-d]pyrimidine C-nucleosides", NUCLEOS NUC, 20(3), 2001, pp. 229-241

Abstract

The Divakar-Reese procedure has been successfully applied for transforming7-oxo-isothiazolo[4,5-d]pyrimidine C-nucleosides (4a,b, 5a,b, 6a) via 1,2,4-triazol-1-yl intermediates (7a,b, 8a,b) into various 7-substituted C-nucleosides 15a,b, 16a,b, 17a, 18a, 19a,b, 20a,b; their subsequent deprotectionprovides novel types of unusual C-glycosides 22b, 23a, 24a,b, 25b, 26b. C-Nucleosides, possessing on its heterocyclic base other than naturally occuring oxo- or amino substituents, are important model compounds for biological or medicinal studies (2,3). We want to report on the synthesis of novel 7-substituted isothiazolo = [4,5-d]pyrimidine C-nucleosides. As we could show in previous papers (1,4), there exists a simple approach to the protected C-glycosides 4-6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:55:47