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Titolo:
Extracellular levels of glucose and lactate measured by quantitative microdialysis in the human brain
Autore:
Langemann, H; Alessandri, B; Mendelowitsch, A; Feuerstein, T; Landolt, H; Gratzl, O;
Indirizzi:
Univ Basel, Cantonal Hosp, Dept Res, Neurosurg Lab,Neurosurg Clin, Basel, Switzerland Univ Basel Basel Switzerland urg Lab,Neurosurg Clin, Basel, Switzerland Cantonal Hosp, Neurosurg Clin, Aarau, Switzerland Cantonal Hosp Aarau Switzerland osp, Neurosurg Clin, Aarau, Switzerland
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 5, volume: 23, anno: 2001,
pagine: 531 - 536
SICI:
0161-6412(200107)23:5<531:ELOGAL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; INTRACEREBRAL MICRODIALYSIS; CEREBRAL MICRODIALYSIS; NEURONAL-ACTIVITY; TISSUE; GLUTAMATE; DELIVERY; STRIATUM; INJURY; OXYGEN;
Keywords:
brain; extracellular; glucose; lactate; microdialysis; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Langemann, H Kantonsspital, Dept Res, Neurosurg Lab, Hebelstr 20, CH-4031 Basel, Switzerland Kantonsspital Hebelstr 20 Basel Switzerland CH-4031 tzerland
Citazione:
H. Langemann et al., "Extracellular levels of glucose and lactate measured by quantitative microdialysis in the human brain", NEUROL RES, 23(5), 2001, pp. 531-536

Abstract

The aim of this study was to use quantitative microdialysis to estimate the true extracellular concentrations of glucose and lactate in minimally disturbed human brain. These values are important as criteria for microdialytical monitoring in critical care patients and for determining therapy. Microdialysis procedures were carried out during tumor operations, the probe being inserted distant from the site of manipulation in minimally disturbed tissue. Two methods were used 1. The zero net flux method of Lonnroth. 2. Thelow flow method (10 mm membrane length, flow rate 0.3 mul min(-1), high invivo recovery). Both methods gave similar values of about 2000 muM for lactate and slightly less for glucose (1700 muM). Glucose levels correspond with those measured by other methods in humans, allowing for the fact that our patients were anesthetised. Extracellular glucose levels were positively correlated with blood glucose values measured before the operation, and with extracellular lactate. Results confirm that extracellular glucose is zerowhen blood glucose is about 2 mM.

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Documento generato il 03/04/20 alle ore 08:00:06