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Titolo:
Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys
Autore:
Schultz, C; Dick, EJ; Cox, AB; Hubbard, GB; Braak, E; Braak, H;
Indirizzi:
Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 nat, D-60590 Frankfurt, Germany USAF, Res Lab, Vet Sci Branch, Brooks AFB, TX USA USAF Brooks AFB TX USAUSAF, Res Lab, Vet Sci Branch, Brooks AFB, TX USA USAF, Res Lab, Directed Energy Bioeffects Div, Brooks AFB, TX USA USAF Brooks AFB TX USA irected Energy Bioeffects Div, Brooks AFB, TX USA SW Fdn Biomed Res, Dept Lab Anim Med, San Antonio, TX 78284 USA SW Fdn Biomed Res San Antonio TX USA 78284 Med, San Antonio, TX 78284 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 4, volume: 22, anno: 2001,
pagine: 677 - 682
SICI:
0197-4580(200107/08)22:4<677:EOSPAB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGYROPHILIC GRAIN DISEASE; PARKINSONS-DISEASE; BALLOONED NEURONS; ROSENTHAL FIBERS; IRON; ACCUMULATION; PIGMENT; BODIES; BRAINS;
Keywords:
alpha B-crystallin; ubiquitin; heat shock proteins; nonhuman primates; iron; Parkinson's disease; spheroids; Hallervorden-Spatz disease; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, C Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 0 Frankfurt, Germany
Citazione:
C. Schultz et al., "Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys", NEUROBIOL A, 22(4), 2001, pp. 677-682

Abstract

Ubiquitin and alpha B-crystallin belong to a class of proteins which are overexpressed in a variety of human neuropathological conditions associated with increased cellular stress. In this study we have examined the brains of aged rhesus monkeys (Macaca mulatta; n = 10, mean age: 39.7 years) using antibodies against the stress proteins ubiquitin, alpha B-crystallin. and heat shock protein 27 (hsp27). Here, we demonstrate an increased expression of ubiquitin, alpha B-crystallin, and hsp27 in spheroid bodies predominantly localized in the globus pallidus and pars reticulata of the substantia nigra. A portion of the pallido-nigral spheroids also contained ferric iron as highlighted by Perls' staining. On the basis of these findings we advancethe hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:42:37