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Titolo:
Influence of diet restriction on NMDA receptor subunits and learning during aging
Autore:
Magnusson, KR;
Indirizzi:
Colorado State Univ, Coll Vet Med & Biomed Sci, Program Mol Cellular & Integrat Neurosci, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 4, volume: 22, anno: 2001,
pagine: 613 - 627
SICI:
0197-4580(200107/08)22:4<613:IODRON>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; LONG-TERM POTENTIATION; AGED RATS; CALORIC RESTRICTION; GLUTAMATE RECEPTORS; SPATIAL INFORMATION; MOLECULAR DIVERSITY; COGNITIVE DECLINE; FRONTAL-CORTEX; ANIMAL-MODELS;
Keywords:
N-methyl-D-aspartate; zetal (NR1); epsilon1(NR2A); epsilon2 (NR2B); cortex; hippocampus; water maze; learning; spatial memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Magnusson, KR Colorado State Univ, Coll Vet Med & Biomed Sci, Program Mol Cellular & Integrat Neurosci, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 s, CO 80523 USA
Citazione:
K.R. Magnusson, "Influence of diet restriction on NMDA receptor subunits and learning during aging", NEUROBIOL A, 22(4), 2001, pp. 613-627

Abstract

This study was designed to determine if changes related to aging and diet in the mRNA expression of subunits of the NMDA receptor were associated with changes in binding to NMDA receptors and learning ability in C57Bl/6 mice. Three age groups (3, 15, and 26-27 months old) and 2 diet groups (ad libitum-fed and diet restricted) were used. The old ad libitum-fed mice had significantly poorer performance in a spatial reference memory task than all other groups. Diet restriction slightly spared glutamate binding to NMDA sites and improved zeta1. but not is an element of2. mRNA expression. Significant correlations were found between NMDA-displaceable [H-3]glutamate binding and both learning ability and is an element of2 and is an element of1 mRNA density in several brain regions. Learning ability in the old mice also correlated with the ratios of mRNA expression for is an element of1 and is an element of2 and/or zeta1 subunits in the parietal cortex and CA1 region of the hippocampus. This suggests that it is the relationship between subunit expression levels that is important for maintaining memory functions in older animals. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:21:14