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Titolo:
Effects of age on tissues and regions of the cerebrum and cerebellum
Autore:
Jernigan, TL; Archibald, SL; Fennema-Notestine, C; Gamst, AC; Stout, JC; Bonner, J; Hesselink, JR;
Indirizzi:
Vet Affairs San Diego Hlthcare Syst, San Diego, CA USA Vet Affairs San Diego Hlthcare Syst San Diego CA USA , San Diego, CA USA Univ Calif San Diego, Dept Psychiat, Brain Image Anal Lab, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 Lab, San Diego, CA 92103 USA Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 osci, San Diego, CA 92103 USA Indiana Univ, Dept Psychol, Bloomington, IN USA Indiana Univ Bloomington IN USA Univ, Dept Psychol, Bloomington, IN USA Chicago Med Sch, N Chicago, IL USA Chicago Med Sch N Chicago IL USAChicago Med Sch, N Chicago, IL USA Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 diol, San Diego, CA 92103 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 4, volume: 22, anno: 2001,
pagine: 581 - 594
SICI:
0197-4580(200107/08)22:4<581:EOAOTA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; HEALTHY ELDERLY SUBJECTS; IN-VIVO; GRAY-MATTER; CARDIOVASCULAR HEALTH; PREFRONTAL GRAY; SEX-DIFFERENCES; HUMAN BRAIN; RESONANCE; ATROPHY;
Keywords:
aging; human; magnetic resonance imaging; gray matter; white matter; white matter abnormality; cerebrum; cerebellum; hippocampus; frontal lobes; Apolipoprotein E epsilon 4 allele;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Jernigan, TL Vet Affairs San Diego Hlthcare Syst, San Diego, CA USA Vet Affairs San Diego Hlthcare Syst San Diego CA USA CA USA
Citazione:
T.L. Jernigan et al., "Effects of age on tissues and regions of the cerebrum and cerebellum", NEUROBIOL A, 22(4), 2001, pp. 581-594

Abstract

Normal volunteers, aged 30 to 99 years, were studied with MRI. Age was related to estimated volumes of: gray matter, white matter, and CSF of the cerebrum and cerebellum; gray matter, white matter, white matter abnormality, and CSF within each cerebral lobe: and gray matter of eight subcortical structures. The results were: 1) Age-related losses in the hippocampus were significantly accelerated relative to gray matter losses elsewhere in the brain. 2) Among the cerebral lobes, the frontal lobes were disproportionately affected by cortical volume loss and increased white matter abnormality. 3)Loss of cerebral and cerebellar white matter occurred later than, but was ultimately greater than, loss of gray matter. It is estimated that between the ages of 30 and 90 volume loss averages 14% in the cerebral cortex, 35% in the hippocampus, and 26%, in the cerebral white matter. Separate analyses were conducted in which genetic risk associated with the Apolipoprotein Eis an element of4 allele was either overrepresented or underrepresented among elderly participants. Accelerated loss of hippocampal volume was observed with both analyses and thus does not appear to be due to the presence ofat-risk subjects. MR signal alterations in the tissues of older individuals pose challenges to the validity of current methods of tissue segmentation. and should be considered in the interpretation of the results. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:33:00