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Titolo:
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
Autore:
Matsushita, S; Arai, H; Yuzuriha, T; Kato, M; Matsui, T; Urakami, K; Higuchi, S;
Indirizzi:
Kurihama Natl Hosp, Natl Inst Alcoholism, Dept Clin Res, Yokosuka, Kanagawa, Japan Kurihama Natl Hosp Yokosuka Kanagawa Japan es, Yokosuka, Kanagawa, Japan Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 eriatr Med, Sendai, Miyagi 980, Japan Hizen Natl Hosp, Dept Psychiat, Saga, Japan Hizen Natl Hosp Saga JapanHizen Natl Hosp, Dept Psychiat, Saga, Japan Tokyo Dent Coll, Dept Neuropsychiat, Chiba, Japan Tokyo Dent Coll Chiba Japan Dent Coll, Dept Neuropsychiat, Chiba, Japan Tottori Univ, Sch Med, Dept Neurol, Tottori 680, Japan Tottori Univ Tottori Japan 680 Sch Med, Dept Neurol, Tottori 680, Japan
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 4, volume: 22, anno: 2001,
pagine: 569 - 574
SICI:
0197-4580(200107/08)22:4<569:NABDGA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-KETOGLUTARATE DEHYDROGENASE; CEREBROSPINAL-FLUID; COMPLEX ACTIVITY; RECEPTOR GENE; ALCOHOLICS; PROTEIN; BRAINS; RISK; ABNORMALITY; ENZYME;
Keywords:
dihydrolipoyl succinyltransferase; polymorphism; apolipoprotein; Alzheimer's disease; Wernicke-Korsakoff syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushita, S Kurihama Natl Hosp, Natl Inst Alcoholism, Dept Clin Res, Yokosuka, Kanagawa, Japan Kurihama Natl Hosp Yokosuka Kanagawa Japan Kanagawa, Japan
Citazione:
S. Matsushita et al., "No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome", NEUROBIOL A, 22(4), 2001, pp. 569-574

Abstract

Among many candidate genes for the genetically heterogeneous Alzheimer's disease (AD), only apolipoprotein E (ApoE) has been confirmed. Another candidate is the dihydrolipoyl succinyltransferase (DLST) gene, one of three components of thiamine-dependent mitochondrial a-ketoglutarate dehydrogenase complex (KGDHC). because KGDHC activity is reported reduced in AD patients. Also characterized by reduced KGDHC activity is another neuropsychiatric disease. Wernicke-Korsakoff syndrome (WKS). which results from thiamine deficiency. Examination of specific DLST gene polymorphism in 247 Japanese AD patients. 53 alcoholic WKS patients, and 368 nondemented Japanese control subjects revealed no significant differences in DLST genotypes and failed to replicate the findings of earlier studies indicating an association between DLST gene polymorphism and AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:23:10