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Titolo:
Removal of contrast media by different extracorporeal treatments
Autore:
Schindler, R; Stahl, C; Venz, S; Ludat, K; Krause, W; Frei, U;
Indirizzi:
Charite, Dept Nephrol & Intens Care Med, Berlin, Germany Charite Berlin Germany Dept Nephrol & Intens Care Med, Berlin, Germany Charite, Dept Radiol, Berlin, Germany Charite Berlin GermanyCharite, Dept Radiol, Berlin, Germany Schering AG, D-1000 Berlin, Germany Schering AG Berlin Germany D-1000Schering AG, D-1000 Berlin, Germany
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 7, volume: 16, anno: 2001,
pagine: 1471 - 1474
SICI:
0931-0509(200107)16:7<1471:ROCMBD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-INSUFFICIENCY; INDUCED NEPHROPATHY; RADIOCONTRAST; HEMODIALYSIS; PREVENTION; NEPHROTOXICITY; MEMBRANES;
Keywords:
acute renal failure; haemodialysis; haemofiltration; iomeprol; radiocontrast media;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Schindler, R Univ Clin Charite, Dept Nephrol & Intens Care Med, Campus Virchow Klinikum,Augustenburger Pl 1, D-13353 Berlin, Germany Univ Clin Charite Campus Virchow Klinikum,Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
R. Schindler et al., "Removal of contrast media by different extracorporeal treatments", NEPH DIAL T, 16(7), 2001, pp. 1471-1474

Abstract

Background. Although the capability poreal treatments after administrationof contrast media to prevent radiocontrast-induced nephropathy is controversial, haemodialysis is performed in many institutions after radiographic procedures. There are conflicting reports on the efficacy of different dialysers and treatment modalities to remove contrast media. Methods, We compared the contrast medium-removing ability of different extracorporeal treatments in a randomized trial. Thirty-nine patients on chronic renal-replacement therapy or with chronic renal failure were randomized to receive low-flux haemodialysis (Low-HD, n=10), high-flux haemodialysis (High-HD, n=10), online haemodiafiltration (HDF, 10 litre substitution, n=10)and online haemofiltration(HF, 18 litre substitution, n=9) after administration of contrast medium during routine radiological procedures. Plasma concentrations of contrast medium (iopromide or iomeprol) were measured by energy-dispersive X-ray fluorescence analysis. Results. The extraction ratio for contrast media was 0.64 +/-0.1 for Low HD (P<0.05 vs High-HD and vs HDF), 0.74<plus/minus>0.1 for High-HD (P<0.05 vs HF), 0.81<plus/minus>0.1 for HDF (P<0.05 vs HF), and 0.62<plus/minus>0.1 for HF. Mean extracorporeal plasma clearances were 82 +/-2 for Low-HD (P<0.05 vs High-HD and vs HDF), 100<plus/minus>2 for High-HD, 115 +/-4 for HDF (P < 0.05 vs HF), and 86<plus/minus>5 ml/min for HF. Conclusions. We conclude that HDF and High-HD remove contrast media more effectively than Low-HD and HF during the time of each treatment session. However, whether this is also true for the overall elimination of contrast media by these different procedures needs to be addressed in future studies, by a precise assessment of the drug time course after the session.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:49:20