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Titolo:
Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients: Chronic Haemodialysis And New Cardiac Markers Evaluation (CHANCE) study
Autore:
Iliou, MC; Fumeron, C; Benoit, MO; Tuppin, P; Le Courvoisier, C; Calonge, VM; Moatti, N; Buisson, C; Jacquot, C;
Indirizzi:
Hop Broussais, Serv Readaptat Cardiaque, F-75014 Paris, France Hop Broussais Paris France F-75014 ptat Cardiaque, F-75014 Paris, France Hop Broussais, Serv Biochim, F-75014 Paris, France Hop Broussais Paris France F-75014 , Serv Biochim, F-75014 Paris, France Hop Broussais, Serv Nephrol, F-75014 Paris, France Hop Broussais Paris France F-75014 , Serv Nephrol, F-75014 Paris, France Hop Broussais, INSERM, U430, F-75014 Paris, France Hop Broussais Paris France F-75014 , INSERM, U430, F-75014 Paris, France Etablissement Francais de Greffes, Paris, France Etablissement Francais deGreffes Paris France e Greffes, Paris, France Assoc Utilisat Rein Artificiel, Paris, France Assoc Utilisat Rein Artificiel Paris France n Artificiel, Paris, France
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 7, volume: 16, anno: 2001,
pagine: 1452 - 1458
SICI:
0931-0509(200107)16:7<1452:FAWISL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-FAILURE; DIALYSIS PATIENTS; SKELETAL-MUSCLE; HEMODIALYSIS; SPECIFICITY; EXPRESSION; DISEASE; INJURY; HEART;
Keywords:
cardiac markers; haemodialysis; left ventricular hypertrophy; renal disease; risk factors; troponin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Iliou, MC Hop Broussais, Serv Readaptat Cardiaque, 96 Rue Didot, F-75014 Paris, France Hop Broussais 96 Rue Didot Paris France F-75014 4 Paris, France
Citazione:
M.C. Iliou et al., "Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients: Chronic Haemodialysis And New Cardiac Markers Evaluation (CHANCE) study", NEPH DIAL T, 16(7), 2001, pp. 1452-1458

Abstract

Background. Serum concentrations of the cardiac troponins (cTn) T and I, specific markers of myocardial injury, are frequently elevated in haemodialysis patients. The clinical relevance of this: is unclear. The aim of this study was to investigate factors associated with increased serum levels of cTn in haemodialysis patients. Methods. We included in this cross-sectional study 258 chronic haemodialysis patients (150 men, age 60 +/- 15 years) without acute coronary symptoms. Clinical data, echocardiographic hypertrophy, biochemical status. and haemodialysis regimen were evaluated for each patient. Pre-dialysis serum cTnT (Elecsys, Roche), cTnI (Stratus and RXL, Dade Berhing), and CK-MB (Stratus,Dade-Berhing) concentrations were determined. Logistic regression was the principal method of analysis. Results. Pre-dialysis levels of cTnT >0.1 ng/ml (n=48. 18.6% of patients) were associated with age (P<0.001). diabetes (P<0.005), history of ischaemic heart disease (P<0.05), and left ventricular hypertrophy (P<0.05). In multivariate analysis, age odds ratio ((OR) 1.04), diabetes (OR 4.9), and indexed left ventricular mass (OR 1.01) were found to be independently associated with cTnT concentration above the threshold. Only six patients had cTnI-Stratus levels >0.6 ng/ml. cTnI-RXL levels >0.3 ng/ml (n=13. 5.0%,) were associated with age (P=0.05) and hypercholesterolaemia (P<0.05). Only age (OR1.06) remained associated in multivariate analysis. Conclusion, Elevated baseline serum levels of cardiac troponins were associated with cardiovascular risk factors. history of ischaemic heart disease and left ventricular hypertrophy in asymptomatic chronic haemodialysis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:22:35