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Titolo:
Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension
Autore:
Peei, G; Itzhakov, E; Wollman, Y; Chernihovsky, T; Grosskopf, I; Segev, D; Silverberg, D; Blum, M; Schwartz, D; Iaina, A;
Indirizzi:
Tel Aviv Med Ctr, Ichilov Hosp, Dept Nephrol, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel IL-64239 rol, IL-64239 Tel Aviv, Israel
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 7, volume: 16, anno: 2001,
pagine: 1436 - 1441
SICI:
0931-0509(200107)16:7<1436:MBANOI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS HYPOTENSION; RENAL-FAILURE; ENHANCED PRODUCTION; HEMODIALYSIS; BLOOD; ACCUMULATION; DYSFUNCTION; GENERATION; MEMBRANE; CELLS;
Keywords:
haemodialysis; hypotension; methylene blue; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Iaina, A Tel Aviv Med Ctr, Ichilov Hosp, Dept Nephrol, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr 6 Weizman St Tel Aviv Israel IL-64239 v, Israel
Citazione:
G. Peei et al., "Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension", NEPH DIAL T, 16(7), 2001, pp. 1436-1441

Abstract

Background. Plasma nitric oxide (NO) levels have been found to be high in haemodialysis (HD) patients, especially in those prone to hypotension in dialysis. The aim of the study was to prevent dialysis hypotension episodes by i.v. administration of methylene blue (MB). an inhibitor of NO activity and or production. Methods. MB was given i.v. in 18 stable HD patients with hypotensive episodes during almost every dialysis, in 18 HD patients without hypotension during dialyses, and in five healthy controls. MB was given as a bolus of 1 mg/kg bodyweight followed by a constant infusion of 0.1 mg/kg bodyweight lasting 210 min until the end of the dialysis session and only as a bolus on a non-dialysis day. Systolic and diastolic blood pressures (BP) were measuredat 10-min intervals during HD sessions with or without MB and on a non-dialysis day with MB. Results, In hypotension-prone patients, MB completely prevented the hypotension during dialysis and increased both systolic and diastolic BP on nondialysis days. In normotensive patients, MB increased BP during the first hour of dialysis and for 90 min on the non-dialysis day. The BP in the healthycontrols remained unchanged. Plasma and platelet NO2 + NO3 (stable metabolites of NO) levels were determined, The NO2+NO3 generation rate in the first postdialysis day was calculated. The plasma and platelet NO2 + NO3 were higher in the hypotensive group than in the normotensive dialysis group. Thegeneration rate of nitrates was higher (P < 0.01) in the hypotensive group(1.21<plus/minus>0.13 mu mol/min and 0.74 +/-0.16 after MB) than in the normotensive patients (0.61 +/-0.11 mu mol min and 0.27 +/-0.14 after MB). Noside-effects were recorded. Conclusions, MB is an efficient therapy in the prevention of dialysis hypotension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:39:10