Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Scintigraphic methods to detect beta 2-microglobulin associated amyloidosis (A beta 2-microglobulin amyloidosis)
Autore:
Floege, J; Schaffer, J; Kock, KM;
Indirizzi:
Univ Aachen, Med Klin 2, Dept Med, Div Nephrol, D-52057 Aachen, Germany Univ Aachen Aachen Germany D-52057 Div Nephrol, D-52057 Aachen, Germany Univ Hannover, Dept Med, Div Nephrol, D-30167 Hannover, Germany Univ Hannover Hannover Germany D-30167 ephrol, D-30167 Hannover, Germany
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
, volume: 16, anno: 2001, supplemento:, 4
pagine: 12 - 16
SICI:
0931-0509(2001)16:<12:SMTDB2>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS-RELATED AMYLOIDOSIS; LONG-TERM HEMODIALYSIS; CARPAL-TUNNEL SYNDROME; P COMPONENT; I-131 BETA-2-MICROGLOBULIN; BONE-CYSTS; BETA(2)-MICROGLOBULIN; ARTHROPATHY; DEPOSITS; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Floege, J Univ Aachen, Med Klin 2, Dept Med, Div Nephrol, D-52057 Aachen, Germany Univ Aachen Aachen Germany D-52057 ol, D-52057 Aachen, Germany
Citazione:
J. Floege et al., "Scintigraphic methods to detect beta 2-microglobulin associated amyloidosis (A beta 2-microglobulin amyloidosis)", NEPH DIAL T, 16, 2001, pp. 12-16

Abstract

beta2-Microglobulin-derived amyloidosis (A beta 2m) represents a major cause or morbidity in patients with end-stage renal disease. Symptoms of A beta 2m amyloid are mainly related to (peri-) articular amyloid deposition. Conventional non-invasive diagnostic techniques, i.e. clinical evaluation, joint ultrasonography or X-ray, computed tomography or magnetic resonance imaging findings, as well as conventional bone scans, suffer from relative non-specificity and/or low sensitivity. Two recent methods, namely scintigraphy with radiolabelled serum amyloid P component (SAP) or with the radiolabelled A beta 2m-precursor protein, beta2-microglobulin (beta 2m), yield more specific information. Using I-123-labelled SAP, A beta 2m deposits have been visualized in several long-term haemodialysis (HD) patients. However, this scan did not show tracer accumulation in other frequently involved sites,such as hips or shoulders, but did frequently label the spleen, which is usually spared from A beta 2m deposits. Scanning with I-131-labelled beta 2m, in contrast, yielded tracer accumulations corresponding to the typical distribution pattern of A beta 2m. Specificity of this method was shown by several methods, and the sensitivity was found to markedly exceed that of combined clinical and radiological investigations. Recently, both the radiation exposure and the optical resolution of this latter scan have been furtherrefined by substituting I-131 with In-111. In a final step we generated recombinant human beta 2m (rh beta 2m) In-111-rh beta 2m again failed to showsignificant tracer accumulation over joint regions in patients on short-term HD without evidence of A beta 2m amyloidosis. In contrast, local tracer accumulations similar to those observed with natural, In-111-labelled beta 2m could be demonstrated in long-term HD patients with evidence of A beta 2m amyloidosis. In conclusion, scintigraphy for A beta 2m with In-111-labelled rh beta 2m provides a homogenous and safe recombinant protein source, and allows for the sensitive and specific non-invasive detection of A beta 2m-amyloid deposits in dialysis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:01:52