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Titolo:
Metalloproteinases in biology and pathology of the nervous system
Autore:
Yong, VW; Power, C; Forsyth, P; Edwards, DR;
Indirizzi:
Univ Calgary, Dept Oncol, Calgary, AB T3A 2Z1, Canada Univ Calgary Calgary AB Canada T3A 2Z1 Oncol, Calgary, AB T3A 2Z1, Canada Univ Calgary, Dept Clin Neurosci, Calgary, AB T3A 2Z1, Canada Univ Calgary Calgary AB Canada T3A 2Z1 rosci, Calgary, AB T3A 2Z1, Canada Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England Univ E Anglia Norwich Norfolk England NR4 7TJ h NR4 7TJ, Norfolk, England
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 7, volume: 2, anno: 2001,
pagine: 502 - 511
SICI:
1471-0048(200107)2:7<502:MIBAPO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; AMYLOID PROTEIN-PRECURSOR; ALPHA-SECRETASE CLEAVAGE; FOCAL CEREBRAL-ISCHEMIA; GELATINASE-A MMP-2; MATRIX-METALLOPROTEINASE; MULTIPLE-SCLEROSIS; IN-VITRO; PLASMINOGEN-ACTIVATOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Yong, VW Univ Calgary, Dept Oncol, 3330 Hosp Dr, Calgary, AB T3A 2Z1, Canada Univ Calgary 3330 Hosp Dr Calgary AB Canada T3A 2Z1 A 2Z1, Canada
Citazione:
V.W. Yong et al., "Metalloproteinases in biology and pathology of the nervous system", NAT REV NEU, 2(7), 2001, pp. 502-511

Abstract

Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some ofthe beneficial functions of MMPs during neural development and speculate on their roles in repair after brain injury. We also introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:19:18