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Titolo:
Alpha-synuclein and neurodegenerative diseases
Autore:
Goedert, M;
Indirizzi:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 7, volume: 2, anno: 2001,
pagine: 492 - 501
SICI:
1471-0048(200107)2:7<492:AAND>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SYSTEM ATROPHY; GLIAL CYTOPLASMIC INCLUSIONS; UBIQUITIN-PROTEIN LIGASE; SPORADIC PARKINSONS-DISEASE; LEWY-BODY-DISEASE; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA; FAMILIAL PARKINSONISM; JUVENILE PARKINSONISM; BETA-SYNUCLEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
129
Recensione:
Indirizzi per estratti:
Indirizzo: Goedert, M MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH bridge CB2 2QH, England
Citazione:
M. Goedert, "Alpha-synuclein and neurodegenerative diseases", NAT REV NEU, 2(7), 2001, pp. 492-501

Abstract

In recent years, two developments have imparted a new direction to research on the aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense mutation in the alpha -synuclein gene is a rare genetic cause of Parkinson's disease. Second, the identification of the alpha -synuclein protein as the main component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of all cases of Parkinson's and several other diseases. The filamentous inclusions of multiple system atrophy are also made of alpha -synuclein. These findings have placed alpha -synuclein dysfunction at the centre of several common neurodegenerative diseases. Here, I review the molecular properties of the synucleins, the different diseases characterized by the accumulation of a-synuclein, and the possible mechanisms by which dysfunction of a-synuclein might lead to neurodegeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:37:13